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Hepatoprotective potential of isolated flavonoids from Trapa natans L. against the paracetamol induced oxidative stress in rats

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Title Hepatoprotective potential of isolated flavonoids from Trapa natans L. against the paracetamol induced oxidative stress in rats
 
Creator Majee, Chandana
Mazumde, Rupa
Choudhary, Alka N
 
Subject Antioxidant
Liver toxicity
Reactive oxygen species
Water Chestnut
 
Description 910-917
Overdose of paracetamol causes liver toxicity, due to oxidative stress by the reactive oxygen species (ROS) that increases
the levels of ALT and AST, and reduces the level of the antioxidant enzymes. Flavonoids are a source of natural antioxidants
that assist in neutralization of ROS. Several studies have suggested that flavonoids can help protect the liver. The Water
Chestnut, Trapa natans L. plants have long been used in the traditional system of medicine and possess considerable
antioxidant potential. In this study, we tried to isolate flavonoids from T. natans L. and evaluate the hepatoprotective potential
of the isolated compound. We isolated flavonoids from the extract of the aerial part of plant and characterized by UV, IR, NMR
and Mass spectroscopy. The isolated flavonoid was induced orally once a day (30 mg/kg). The test drug (isolated compound)
could lower the elevated levels of serum enzymes such as glutamate oxaloacetate transaminase (AST), serum glutamate
pyruvate transaminase (ALT), alkaline phosphatase (ALP) and total bilirubin. Silymarin (30 mg/kg) was taken as a standard
drug that exhibits significant hepatoprotective activity against the paracetamol induced hepatotoxicity model in Wistar albino
rats. The histopathological study of rat liver also strengthens biochemical evaluation analysis. Based on the experimental
results, it can be concluded that the isolated flavonoids act as hepatoprotective agents in rats.
 
Date 2022-12-02T06:18:08Z
2022-12-02T06:18:08Z
2022-12
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/60991
https://doi.org/10.56042/ijeb.v60i12.55735
 
Language en
en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.60(12) [Dec 2022]