Effect of SKB-Gutbiotic on acetic acid induced ulcerative colitis in male Wistar rats
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Title |
Effect of SKB-Gutbiotic on acetic acid induced ulcerative colitis in male Wistar rats
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Creator |
Mohan, Mahalaxmi
Saudagar, Parag Dalvi, Mitali |
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Subject |
Antioxidant
Colitis Inflammatory bowel disease (IBD) Prednisolone Probiotic |
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Description |
894-901
Inflammatory bowel disease (IBD) is a chronic intestinal inflammation gaining increasing attention as it affects considerable number of humans. IBD is reported as ulcerative colitis (UC) and Crohn's disease (CD) Conventional therapies currently available are not satisfactory. Therefore, here, we investigated the effect of SKB-Gutbiotic on acetic acid induced ulcerative coltis (UC) in male Wistar rats. Male Wistar rats, 200-250 g were divided into six groups as follows: Gr. I (control) received 10 mL/kg of distilled water for 21 consecutive days. Gr. II received 2 mL of 4% acetic acid solution once intra rectally for induction of colitis. Gr. III received 2 mg/kg prednisolone as standard control. Groups IV, V & VI were treated with SKB-Gutbiotic @2×109, 20×109 and 50×109 Cfu/kg, respectively. All the animals from each group were sacrificed 24 h after the induction of colitis. Disease activity index, macroscopical damage, hematological parameters, level of superoxide dismutase (SOD), myeloperoxidase (MPO), reduced glutathione (GSH) and histopathological alterations were evaluated. Acetic acid-induced colitis significantly caused alteration in disease activity index, macroscopical damage, MPO and GSH levels (P |
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Date |
2022-12-02T06:23:29Z
2022-12-02T06:23:29Z 2022-12 |
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Type |
Article
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Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/60993 https://doi.org/10.56042/ijeb.v60i12.69115 |
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Language |
en
en |
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Publisher |
NIScPR-CSIR,India
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Source |
IJEB Vol.60(12) [Dec 2022]
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