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Effect of SKB-Gutbiotic on acetic acid induced ulcerative colitis in male Wistar rats

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Title Effect of SKB-Gutbiotic on acetic acid induced ulcerative colitis in male Wistar rats
 
Creator Mohan, Mahalaxmi
Saudagar, Parag
Dalvi, Mitali
 
Subject Antioxidant
Colitis
Inflammatory bowel disease (IBD)
Prednisolone
Probiotic
 
Description 894-901
Inflammatory bowel disease (IBD) is a chronic intestinal inflammation gaining increasing attention as it affects
considerable number of humans. IBD is reported as ulcerative colitis (UC) and Crohn's disease (CD) Conventional therapies
currently available are not satisfactory. Therefore, here, we investigated the effect of SKB-Gutbiotic on acetic acid induced
ulcerative coltis (UC) in male Wistar rats. Male Wistar rats, 200-250 g were divided into six groups as follows: Gr. I
(control) received 10 mL/kg of distilled water for 21 consecutive days. Gr. II received 2 mL of 4% acetic acid solution once
intra rectally for induction of colitis. Gr. III received 2 mg/kg prednisolone as standard control. Groups IV, V & VI were
treated with SKB-Gutbiotic @2×109, 20×109 and 50×109 Cfu/kg, respectively. All the animals from each group were
sacrificed 24 h after the induction of colitis. Disease activity index, macroscopical damage, hematological parameters, level
of superoxide dismutase (SOD), myeloperoxidase (MPO), reduced glutathione (GSH) and histopathological alterations were
evaluated. Acetic acid-induced colitis significantly caused alteration in disease activity index, macroscopical damage, MPO
and GSH levels (P
 
Date 2022-12-02T06:23:29Z
2022-12-02T06:23:29Z
2022-12
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/60993
https://doi.org/10.56042/ijeb.v60i12.69115
 
Language en
en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.60(12) [Dec 2022]