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Pharmacological potential of seaweed-associated heterotrophic bacterium Bacillus atrophaeus

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Relation http://eprints.cmfri.org.in/16504/
https://link.springer.com/article/10.1007/s00203-022-03338-2
https://doi.org/10.1007/s00203-022-03338-2
 
Title Pharmacological potential of seaweed-associated heterotrophic bacterium Bacillus atrophaeus
 
Creator Varghese, Chesvin
Chakraborty, Kajal
Asharaf, Sumayya
 
Subject Biochemistry
Seaweed
 
Description Extremities in marine environmental conditions led the marine macroalga-associated bacteria to adapt and biosynthesize potential bioactive agents. The myriad of marine macroalgae and the bacterial flora they are associated with constitute a potential source of bioactive components with significant biotechnological and pharmacological applications. Heterotrophic bacteria associated with the intertidal macroalgae were isolated and assessed for their pharmacological properties. Subsequently, Firmicutes dominated more than half of the 152 cultivable isolates from macroalgae-associated bacteria collected from the Gulf of Mannar (9°17′0′′ N, 79°7′0′′ E), on Peninsular India’s southern coast. A total of 43 of those demonstrated steady antibacterial activities against a wide range of nosocomial pathogens. Among the bacteria isolated from marine macroalgae, Bacillus atrophaeus SHB2097 (MW821482) exhibited significant antimicrobial activities against clinically important pathogens. Organic extract of B. atrophaeus SHB2097 showed potential antimicrobial activities against test pathogens (minimum inhibitory concentration 6.25 µg/mL). Organic extract of B. atrophaeus SHB2097 revealed promising inhibition potential against cyclooxygenase-2 (IC90 53.26 µg/mL) and 5-lipoxygenase (IC90 9.74 µg/mL). The carbolytic enzyme α-glucosidase inhibition potential of the organic extract of the studied heterotrophic bacterium was significantly greater than (IC90 118 µg/mL) than that displayed by acarbose (IC90 645 µg/mL, p 
 
Publisher Springer
 
Date 2023
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/16504/1/Archives%20of%20Microbiology_2023_Kajal%20Chakraborty.pdf
Varghese, Chesvin and Chakraborty, Kajal and Asharaf, Sumayya (2023) Pharmacological potential of seaweed-associated heterotrophic bacterium Bacillus atrophaeus. Archives of Microbiology, 205 (10). pp. 1-12. ISSN 1432-072X