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<p>Anti-diabetic potential of fruit extracts of <em>Flacourtia indica </em>(Burm. F.) Merr-An <em>in-vitro</em> study</p>

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Title Statement <p>Anti-diabetic potential of fruit extracts of <em>Flacourtia indica </em>(Burm. F.) Merr-An <em>in-vitro</em> study</p>
 
Added Entry - Uncontrolled Name Makuttan, Sudhina ; Department of Pharmaceutical Chemistry, Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to be University), Deralakatte 575018, Mangaluru, Karnataka, India
Fernandes, Jennifer ; Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Paneer, Deralakatte 575018, Mangaluru, Karnataka, India
G, Ambily P; Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Paneer, Deralakatte 575018, Mangaluru, Karnataka, India
 
Uncontrolled Index Term Pharmaceutical Chemistry
Acarbose; Alpha-amylase; Alpha-glucosidase; Anti-diabetic; Flacourtia indica
 
Summary, etc. <p style="text-align: justify;">Diabetes mellitus is one of the biggest global health problems requiring preventive and new therapeutic interventions. There is a need for safe, reliable, and cost-effective anti-diabetic drugs, and investigating medicinal plants for new anti-diabetic medications is an exciting research field. Thus, the present study examined the <em>in-vitro</em> anti-diabetic activity of ethanolic and aqueous extracts of <em>Flacourtia indica </em>(Burm. F.) Merr (Flacourtiaceae) fruits by different enzyme inhibition assay methods. Alpha-amylase and Alpha-glucosidase are the principal enzymes present in the human body which helps in the digestion of carbohydrates. Inhibition of these enzymes slows down the absorption of glucose and lowers the sugar level in the blood. Both extracts showed potent inhibitory activity against these enzymes in a dose-dependent manner. The highest percentage of inhibition is exhibited by ethanolic extract at a concentration of 100 µg/mL with an IC<sub>50</sub> value of 84.02. The results were compared with the standard drug Acarbose, a competitive inhibitor of both enzymes. The ethanolic extract was subjected to preliminary phytochemical analysis to find out different chemical constituents. It revealed the presence of reducing sugars, flavonoids, phenolic compounds, terpenoids, fatty acids, and steroids. Therefore, the current study proved that both ethanolic and aqueous extracts of <em>F. indica</em> fruits possess bioactive constituents that could be responsible for the anti-diabetic activity.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-12-05 09:59:16
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/48344
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 13, ##issue.no## 4 (2022): December 2022 (Ahead of Print)
 
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