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The impact of walnut leaf<em> </em>on the lipid and glucose profiles in diabetic patients: A systematic review and meta-analysis

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Title Statement The impact of walnut leaf<em> </em>on the lipid and glucose profiles in diabetic patients: A systematic review and meta-analysis
 
Added Entry - Uncontrolled Name Fakhri, Moloud ; Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran 48168 95475
Yousefi, Seyde Sedighe; Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran 48168 95475 Department of Persian Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran 48168 95475
Moosazadeh, Mahmood ; Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran 48168 95475
Azadbakht, Mohammad ; Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran 48168 95475
Fakheri, Hafez ; Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran 48168 95475
Mazandaran University of Medical Sciences
 
Uncontrolled Index Term Blood lipids; Blood sugar; Diabetic patients; Meta-analysis; Systematic review; Walnut leaf
 
Summary, etc. <p style="text-align: justify;">Managing risk factors associated with cardiovascular diseases, such as blood lipids and blood sugar in people with diabetes (PWDs), is important. Besides antidiabetic medicines, herbal remedies such as walnut leaves have long been utilized to decrease blood sugar and blood lipid levels in PWDs. Hence, this study aimed to investigate the impact of walnut leaf<em> </em>on the lipid and glucose profiles of PWDs through a systematic review and meta-analysis. To gain access to the primary empirical studies, domestic and international databases were searched using MeSH keywords. The databases included Barakat Gostar, SID, Magiran, IranDoc, PubMed, Scopus, Web of Science, Embase, Cochrane, International Standard Randomized Controlled Trial Number (ISRCTN), International Clinical Trials Registry Platform (ICTRP), and Clinical Trial.gov (a clinical trial registration system). Data analysis was performed within Stata 14 software. The <em>P</em>-value was considered <em>P</em> &lt;0.05. In 4 studies with a sample size of 101 individuals, which were published between 2014 and 2018, post-test scores of the treatment and control groups pointed out that the difference between insulin and FBS levels was statistically significant. The FBS level was higher in the control group than in the treatment group. However, their insulin level was lower than those in the treatment group. The difference between the levels of HbA1C, cholesterol, triglyceride, LDL, HDL, AST, ALT, ALP, and creatinine in the control and treatment groups was not statistically significant. The pre and post-test scores of the treatment group were compared. The levels of FBS, HbA1C, and LDL decreased significantly, while the patients' insulin levels increased remarkably. No noticeable correlation was observed in other lipid profiles. Due to the thoroughly limited research resources, further studies are required to confirm the findings more confidently.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2022-12-05 09:59:16
 
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Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 13, ##issue.no## 4 (2022): December 2022 (Ahead of Print)
 
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