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First report of a glycosaminoglycan‐xylopyranan from the buccinid gastropod mollusk Babylonia spirata attenuating proinflammatory 5‐lipoxygenase

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Relation http://eprints.cmfri.org.in/13959/
https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.13082
DOI: 10.1111/jfbc.13082
 
Title First report of a glycosaminoglycan‐xylopyranan from the
buccinid gastropod mollusk Babylonia spirata attenuating
proinflammatory 5‐lipoxygenase
 
Creator Chakraborty, Kajal
Salas, Soumya
 
Subject Bioactive compound
New record
Gastropods
Fish Biotechnology
 
Description A previously undescribed xylated glycosaminoglycan characterized as β‐D‐
Xylop(1 → 3)‐(⋯ → 4)‐GlcpA(1 → 3)‐GlcpNAc(1 → ⋯) was purified from the buccinid
gastropod Babylonia spirata and was evaluated for pharmacological properties using
different in vitro models. The glycosaminoglycan‐xylopyranan displayed prospective
free radical quenching activities (IC50 < 0.7 mg/ml), whereas it exhibited potentially
greater attenuation against the inductive proinflammatory enzyme 5‐lipoxygenase
(5‐LOX, IC50 0.36 mg/ml) than the synthetic nonsteroidal anti‐inflammatory drug as‐
pirin (0.42). Gel permeation chromatography analysis specified the average molecular
mass of the purified polysaccharide to be 231.88 kDa. The linkage sites, anomeric
configuration, and the sequence of sugar residues of the purified xylated glycosami‐
noglycan were attributed by the inter‐residue correlation obtained via two‐dimen‐
sional nuclear resonance spectroscopic techniques. The results specified that the
studied compound was composed of GlcpA(1 → 3)‐GlcpNAc (1 → ⋯) disaccharide
repeating unit in the glycosaminoglycan backbone, with the xylose residues branch‐
ing as C‐3 substituents of the GlcpA. .
 
Date 2019
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/13959/1/Journal%20of%20Food%20Biochemistry_2019_Kajal%20Chakraborty_First%20report%20of%20a%20glycosaminoglycan%E2%80%90xylopyranan%20from%20the%20buccinid%20gastropod%20mollusk%20Babylonia%20spirata.pdf
Chakraborty, Kajal and Salas, Soumya (2019) First report of a glycosaminoglycan‐xylopyranan from the buccinid gastropod mollusk Babylonia spirata attenuating proinflammatory 5‐lipoxygenase. Journal of Food Biochemistry. pp. 1-9. ISSN 1745–4514