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First report of spiro-compounds from marine macroalga Gracilaria salicornia: prospective natural anti-inflammatory agents attenuate 5- lipoxygenase and cyclooxygenase-2

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Relation http://eprints.cmfri.org.in/14929/
https://www.tandfonline.com/doi/abs/10.1080/14786419.2019.1608545
https://doi.org/10.1080/14786419.2019.1608545
 
Title First report of spiro-compounds from marine
macroalga Gracilaria salicornia: prospective
natural anti-inflammatory agents attenuate 5-
lipoxygenase and cyclooxygenase-2
 
Creator Chakraborty, Kajal
Antony, Tima
 
Subject Bioprospecting
New record
Bioactive compounds
Algae
 
Description The inflammation pathology is an orchestrated biological process and the dual inhibition of pro-inflammatory enzymes 5-lipoxygenase and cyclooxygenase-2 has been found to be an effective approach against inflammation. This study involves the characterisation of two previously undescribed spiro[5.5]undecanes, 3-(hydroxymethyl)-7-(methoxymethyl)-3,11-dimethyl-9-oxospiro[5.5]undec-4-en-10-methylbutanoate (1) and 4-ethoxy-11,11-dimethyl-7-methylene-8-(propionyloxy)spiro[5.5]undec-2-en-104,106-dihydroxytetrahydro-2H-pyran-10-carboxylate (2) with potential anti-inflammatory properties, from seaweed Gracilaria salicornia by extensive-spectroscopic-experiments. These metabolites recorded prospective bioactivities against 5-lipoxygenase (IC50 
 
Publisher Taylor and Francis
 
Date 2021
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/14929/1/Natural%20Product%20Research_2021_Kajal%20Chakraborty.pdf
Chakraborty, Kajal and Antony, Tima (2021) First report of spiro-compounds from marine macroalga Gracilaria salicornia: prospective natural anti-inflammatory agents attenuate 5- lipoxygenase and cyclooxygenase-2. Natural Product Research, 35 (5). pp. 770-781. ISSN 1478-6427 (Online)