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First report of antioxidant 1H-benzochromenone from muricid gastropod Chicoreus ramosus as dual inhibitors of pro-inflammatory 5-lipoxygenase and carbolytic enzymes

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Relation http://eprints.cmfri.org.in/15160/
https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1647428
https://doi.org/10.1080/14786419.2019.1647428
 
Title First report of antioxidant 1H-benzochromenone from
muricid gastropod Chicoreus ramosus as dual inhibitors of
pro-inflammatory 5-lipoxygenase and carbolytic enzymes
 
Creator Chakraborty, Kajal
Salas, Soumya
 
Subject Bioprospecting
New record
Biochemistry
Gastropods
 
Description Chromene derivatives with manifold structural framework and
pharmacological properties were ubiquitous in the mollusks of
marine origin. A previously undescribed 1H-benzochromenone
was isolated through bioassay-guided chromatographic purification
of the organic extract of the marine gastropod mollusk
Chicoreus ramosus. The compound was characterised as 6-(20,20-
dimethyl)-30-en-10-yl-10-oxy)-3-hydroxy-1H-benzo[c]chromene-
2(10aH)-one based on integrated spectroscopic analysis. The antioxidant
studies by employing the stable free radicals reported
that the antioxidant activity (IC50 1.4–1.6 mM) was comparable to
a-tocopherol (IC50 1.4–1.7 mM). The attenuating potential of the
studied compound against pro-inflammatory 5-lipoxygenase (IC50
2.12 mM) was significantly greater than that exhibited by antiinflammatory
drug ibuprofen (IC50 4.4 mM), whereas its inhibitory
properties against carbolytic a-amylase (IC50 �0.72 mM) was comparable
with that displayed by acarbose (IC50 0.43 mM). The present
study recognised the potential of 1H-benzochromenone
derivative isolated from C. ramosus as important pharmaceutical
lead with anti-diabetic and anti-inflammatory potentials to
reduce the risk of hyperglycaemia and inflammatory pathologies.
 
Publisher Taylor and Francis
 
Date 2021
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/15160/1/NATURAL%20PRODUCT%20RESEARCH_2021_Kajal%20Chakraborty_First%20report%20of%20antioxidant%201H%20benzochromenone%20from%20muricid%20gastropod%20Chicoreus%20ramosus.pdf
Chakraborty, Kajal and Salas, Soumya (2021) First report of antioxidant 1H-benzochromenone from muricid gastropod Chicoreus ramosus as dual inhibitors of pro-inflammatory 5-lipoxygenase and carbolytic enzymes. Natural Product Research, 35 (12). pp. 1949-1958. ISSN 1478-6427 (Online)