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Effect of Quaternary Ammonium Surfactant on Buccal Permeation of Budesonide Film Formulation: In Silico Docking Studies

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Title Effect of Quaternary Ammonium Surfactant on Buccal Permeation of Budesonide Film Formulation: In Silico Docking Studies
 
Creator Pattanaik, Sunil
Nandi, Souvik
Swain, Rakesh
Sahoo, Rudra Narayana
Nanda, Ashirbad
Mallick, Subrata
 
Subject Buccoadhesive film
Buccal permeation
Ex vivo permeation
Glucocorticosteroid
Immunosuppressant
Quaternary ammonium compounds
 
Description 1259-1266
Budesonide, an immunosuppressant glucocorticosteroid generally used to ameliorate chronic inflammation. Low
bioavailability due to first pass metabolism decreases its therapeutic activity. The present study focuses on the formulation of a
biodegradable buccoadhesive film for improvement of buccalpermeation. Transparent buccoadhesive films were prepared by
incorporating budesonide in HPMC matrix with triethalonamine as a plasticizer and a number of surfactants. Absence of the
characteristic drug melting peak at 252C in Differential Scanning Calorimetry (DSC) thermogram study confirmed almost
complete amorphization of the drug to a homogenous solid-solid mixture in the film. The characteristic Fourier-Transform
Infrared Spectroscopy (FTIR) peak of pure drug showed the carbonyl stretching in between 1600–1900 cm−1 and C–O
stretching at 1095 cm−1. Broadening of C–O stretching and masking of carbonyl stretching confirmed the drug polymer
interaction. In vitro dissolution and ex-vivo buccal tissue permeation revealed upto 72% and more than 58% respectively using
surfactants upto 6 hour of study. Enhanced buccal permeability and flux were found in presence of surfactant compared to its
absence. New film formulation could be developed including surfactant for improved buccal permeation with expected
increased bioavailability. The in silico study confirmed about a stable interaction between drug and polymer (−3.1 kcal/mol).
 
Date 2022-12-07T12:00:20Z
2022-12-07T12:00:20Z
2022-12
 
Type Article
 
Identifier 0022-4456 (Print); 0975-1084 (Online)
http://nopr.niscpr.res.in/handle/123456789/61007
https://doi.org/10.56042/jsir.v81i12.61765
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source JSIR Vol.81(12) [December 2022]