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Construction, characterization and antibacterial activity of pyrazolone, thiohydantoin and their derivatives

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Title Construction, characterization and antibacterial activity of pyrazolone, thiohydantoin and their derivatives
 
Creator Michael, Osahon
Tailor, Giriraj
Singh, Saurabh
Sarma, Bhupendra Kr.
Teli, Pankaj
 
Subject Antibacterial activity
Hydantoin
Pyrazole
Pyrazolone
Thiohydantoin
 
Description 1323-1327
Heterocyclic organic compounds play pivotal roles in drug synthesis and continue to remain a fundamental area of research interest. The present study reports the synthesis, characterization and antibacterial activities of synthesized organic compounds containing pyrazolone and thiohydantoin moieties. Pyrazolone and thiohydantoin scaffolds have been constructed using well-defined methods and their derivatives have been synthesized Structural elucidation has been achieved via IR and NMR spectroscopy techniques. The synthesized compounds have been screened for antimicrobial activity at 50 μg/mL concentration, against three pathogenic micro-organisms, viz: E. coli, K. pneumonia and P. aeruginosa, using the agar diffusion cup plate method. Ciprofloxacin is used as control. Interestingly, all the compounds have exhibited antimicrobial activities. Compound 2b have shown the highest sensitivity against P. aeruginosa with zone of inhibition (ZOI) of 13 mm. Compounds 1a and 2a have shown highest activity against K.pneumonia with ZOI 11 mm each. Compound 2a has shown highest sensitivity against E. coli with ZOI of 8 mm. These findings indicate that the synthesized compounds are pure and possess therapeutic properties.
 
Date 2022-12-15T05:18:24Z
2022-12-15T05:18:24Z
2022-12
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61010
https://doi.org/10.56042/ijc.v61i12.69452
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(12) [Dec 2022]