Facile and efficient one-pot multicomponent synthesis of a new class of substituted pyrimidine containing imidazoles catalyzed by ceric ammonium nitrate: Screening in vitro microbiological evaluation with various microorganisms
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Title |
Facile and efficient one-pot multicomponent synthesis of a new class of substituted pyrimidine containing imidazoles catalyzed by ceric ammonium nitrate: Screening in vitro microbiological evaluation with various microorganisms
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Creator |
Rajeev, P V
Begam, A K Ameerunisha Keerthana, R Thanusu, J |
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Subject |
Ceric ammonium nitrate
Imidazole One-pot synthesis Antimicrobial |
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Description |
1295-1302
An effective and simple method for the one-pot synthesis of 4,6-diaryl-2-(2-aryl-4,5-diphenyl-1H-imidazol-1-yl)pyrimidines 13-24 from substituted 2-amino pyrimidine 1-12, benzil, substituted aromatic aldehyde and ammonium acetate in methanol by using ceric ammonium nitrate (CAN) as catalyst has been described. This CAN catalyzed reactions are carried out at a temperature of 70-75°C and give very high yields in a lesser reaction time. All the synthesized compounds have been characterized by elemental analysis, FT-IR, 1H NMR 13C NMR and MS spectral data. All the newly synthesized compounds are tested for their in vitro antimicrobial activity against selected clinically isolated bacterial and fungal strains by disc diffusion and minimum inhibitory concentration method. |
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Date |
2022-12-15T05:36:11Z
2022-12-15T05:36:11Z 2022-12 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61014 https://doi.org/10.56042/ijc.v61i12.69479 |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJC Vol.61(12) [Dec 2022]
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