Record Details

Synthesis of 2-[{2-(1-Acyl-3-aryl-4,5-dihydro-1H-pyrazol-5-yl)phenoxy}methyl]- 5-aryl-1,3,4-oxadiazoles and related compounds as potential pesticides

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Synthesis of 2-[{2-(1-Acyl-3-aryl-4,5-dihydro-1H-pyrazol-5-yl)phenoxy}methyl]- 5-aryl-1,3,4-oxadiazoles and related compounds as potential pesticides
 
Creator Saini, Chhavi
Sangwan, Naresh K
 
Subject Dihydropyrazoles
Oxadiazoles
Pyrazolyloxadiazoles
Antifungal activity
Pesticidal activity
 
Description 1257-1263
Cyclization of substituted chalkones 3a,b with hydrazine hydrate followed by acylation of the resulting 3-aryl-4,5-
dihydro-5-(2-hydroxyphenyl)-1H-pyrazoles (4a,b) with alkanoic acids furnished 1-acyl-3-aryl-4,5-dihydro-5-(2-
hydroxyphenyl)-1H-pyrazoles (5a-d). The compounds 5a-d are also directly prepared by refluxing 3a,b with hydrazine
hydrate in alkanoic acids. Alkylation of 5a-d with ethyl chloroacetate yields the corresponding aryloxyacetates 6a-d.
Aminolysis of the ester 6a-d results in the formation of corresponding substituted aryloxyacetamides 7a-ℓ. Hydrazinolysis of
esters 6a-d with hydrazine hydrate followed by cyclization of the resulting aryloxyacetic acid hydrazides 8a-d with aromatic
acids in refluxing POCl3 affords the title compounds 9a-t. The compounds 3-9 have been evaluated for their in vitro growthinhibitory
activity against four fungal pests, Alternaria helianthus, Colletotrichum falcatum, fusarium oxysporum and
Rhizoctonia solani. Many of the compounds have displayed promising activity at different concentrations ranging from
3.13 – 100 mg L-1.
 
Date 2022-12-15T06:04:01Z
2022-12-15T06:04:01Z
2022-12
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61019
https://doi.org/10.56042/ijc.v61i12.69441
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.61(12) [Dec 2022]