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<p>Effect of Quaternary Ammonium Surfactant on Buccal Permeation of Budesonide Film Formulation: <em>In Silico</em> Docking Studies</p><strong></strong>

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Title Statement <p>Effect of Quaternary Ammonium Surfactant on Buccal Permeation of Budesonide Film Formulation: <em>In Silico</em> Docking Studies</p><strong></strong>
 
Added Entry - Uncontrolled Name Pattanaik, Sunil ; Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar 751003, Odisha, India
Nandi, Souvik ; Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar 751003, Odisha, India
Swain, Rakesh ; Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar 751003, Odisha, India
Sahoo, Rudra Narayana ; Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar 751003, Odisha, India School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha 752 050, India
Nanda, Ashirbad ; Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar 751003, Odisha, India School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha 752 050, India
Mallick, Subrata ; Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Kalinga Nagar, Bhubaneswar 751003, Odisha, India
 
Uncontrolled Index Term Buccoadhesive film, Buccal permeation, Ex vivo permeation, Glucocorticosteroid, Immunosuppressant, Quaternary ammonium compounds
 
Summary, etc. <p class="Abstract">Budesonide, an immunosuppressant glucocorticosteroid generally used to ameliorate chronic inflammation. Low bioavailability due to first pass metabolism decreases its therapeutic activity. The present study focuses on the formulation of a biodegradable buccoadhesive film for improvement of buccalpermeation. Transparent buccoadhesive films were prepared by incorporating budesonide in HPMC matrix with triethalonamine as a plasticizer and a number of surfactants. Absence of the characteristic drug melting peak at 252°C in Differential Scanning Calorimetry (DSC) thermogram study confirmed almost complete amorphization of the drug to a homogenous solid-solid mixture in the film. The characteristic Fourier-Transform Infrared Spectroscopy (FTIR) peak of pure drug showed the carbonyl stretching in between 1600–1900 cm<sup>−1 </sup>and C–O stretching at 1095 cm<sup>−1</sup>. Broadening of C–O stretching and masking of carbonyl stretching confirmed the drug polymer interaction. <em>In vitro</em> dissolution and <em>ex-vivo </em>buccal tissue permeation revealed upto 72% and more than 58% respectively using surfactants upto 6 hour of study. Enhanced buccal permeability and flux were found in presence of surfactant compared to its absence. New film formulation could be developed including surfactant for improved buccal permeation with expected increased bioavailability. The <em>in silico</em> study confirmed about a stable interaction between drug and polymer (−3.1 kcal/mol).</p>
 
Publication, Distribution, Etc. Journal of Scientific & Industrial Research
2022-12-15 12:44:42
 
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http://op.niscair.res.in/index.php/JSIR/article/view/61765
 
Data Source Entry Journal of Scientific & Industrial Research; ##issue.vol## 81, ##issue.no## 12 (2022): Journal of Scientific & Industrial Research
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/JSIR/article/download/61765/465602922
http://op.niscair.res.in/index.php/JSIR/article/download/61765/465602924
http://op.niscair.res.in/index.php/JSIR/article/download/61765/465602925
http://op.niscair.res.in/index.php/JSIR/article/download/61765/465602928
http://op.niscair.res.in/index.php/JSIR/article/download/61765/465602929
http://op.niscair.res.in/index.php/JSIR/article/download/61765/465602930