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Efficient row-column designs for microarray experiments

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Title Efficient row-column designs for microarray experiments
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Creator Ananta Sarkar
Rajender Parsad
V.K. Gupta
Kashinath Chatterjee
Abhishek Rathore
 
Subject Microarray experiments
Fixed/Mixed effects model
Row-column designs
A-efficiency
D-efficiency
 
Description Not Available
This article deals with the problem of obtaining efficient designs for 2-color microarray experiments where same set of genes are spotted on each array. In the literature, optimality aspects of designs for microarray experiments have been investigated under a restricted model invloving array and variety effects. The dye effects have been ignored from the model. If dye effects are also included in the model, then the structure of the design becomes that of a row-column design where arrays represent columns, dyes represent rows and varieties represent treatments. Further, the array effects in microarray experiments may be taken as random (see e.g. Kerr and Churchill (2001a), Lee(2004)). For obtaining efficient row-column designs under fixed/mixed effects model, exchange and interchange algorithms of Eccleston and Jones(1980) and Rathore et al. (2006) have been modified. The algorithm has been translated into a computer program using Microsoft Visual C++. The algorithm is general in nature and can be used for generating efficient row-column designs for any 2
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Date 2017-07-20T12:34:09Z
2017-07-20T12:34:09Z
2010-04
 
Type Research Paper
 
Identifier Sarkar, Ananta, Parsad, Rajender, Gupta, V.K., Chatterjee, Kashinath and Rathore, Abhishek(2010). Efficient row-column designs for microarray experiments. Journal of Indian Society of Agricultural Statistics, 64(1), 89-117.
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http://krishi.icar.gov.in/jspui/handle/123456789/4877
 
Language English
 
Relation Not Available;
 
Publisher Indian Society of Agricultural Statistics