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Efficient block designs for 2-colour microarray experiments

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Title Efficient block designs for 2-colour microarray experiments
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Creator Ananta Sarkar
Rajender Parsad
Abhishek Rathore
V.K. Gupta
 
Subject Microarray experiments
mixed effects models
A-efficiency
D-efficiency
 
Description Not Available
This article deals with the problem of obtaining efficient designs for 2-colour microarray experiments. If arrays are considered as blocks and varieties as treatments and the number of varieties that can be accommodated on each arrary as block size, then a classical incomplete block design can be useful for microarray experiments. Since only two varieties can be accommodated on one array in 2-colour microarray experiment, effects due to arrays may be considered as random. To deal with the problem of obtaining an efficient design when array effects are random, lower bounds to A- and D-efficiencies of the design in a given class of designs have been obtained for block designs under a mixed effects model. For obtaining efficient block designs under fixed/mixed effects model for microarray experiments, the exchange and interchange algorithm of Rathore et. al. (2006) was modified by incorporating the procedure of translated into a computer program using Microsoft Visual C++. The algorithm is general in nature and can be used for generation of efficient block design for any 2
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Date 2017-09-05T08:08:08Z
2017-09-05T08:08:08Z
2007-08
 
Type Research Paper
 
Identifier Sarkar, Ananta, Parsad, Rajender, Rathore, Abhishek and Gupta, V.K. (2007). Efficient block designs for 2-colour microarray experiments. Journal of Indian Society of Agricultural Statistics, 61(2), 227-248.
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http://krishi.icar.gov.in/jspui/handle/123456789/5262
 
Language English
 
Relation Not Available;
 
Publisher Indian Society of Agricultural Statistics