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Hyaluronidase an enzyme in snake venom and its natural inhibitors: A Review

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Title Hyaluronidase an enzyme in snake venom and its natural inhibitors: A Review
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Creator Pushpendra Singh, Mohammad Yasir, Ruchi Khare2, Manish Kumar Tripathi, Manoj Kumar Tripathi ,Rahul Shrivastava
 
Subject Hyaluronidase; Zootoxin; Snake venom; Hyaluronic acid; Spreading factor
 
Description Not Available
Snakebite causes the highest rate of injury and among the population, especially in Asian countries. Snake venom is a type of zootoxins composed of a highly complex mixture of enzymes including phospholipase A2, hyaluronidase, L-amino acid oxidase, acetylcholine esterase, phosphodiester, and low molecular weight polypeptide. The hyaluronidase or hyaluronic glucosidase venom enzyme is considered a “spreading factor” as it hydrolyzes the hyaluronic acid (generally known as hyaluronan), which plays an essential role of cell to cell adhesion in the extracellular matrix of tissue. Secondary metabolites present in a crude extract of medicinal plants are considered as capable venom neutralizing agents as they have no side effect and can neutralize a wide range of snake venom enzymes. The objective of this review is to collect, simplify and explain the role along with the importance of inhibition of hyaluronic glucosidase in snake venoms. All the accessible information on hyaluronic glucosidases was collected via electronic search (using Google Books, PubMed, SciFinder, Scopus, Google Scholar, and Web of Science) and articles of peer-reviewed journals. This review contains a brief description of the structure, occurrence, mechanism, assay procedures, and phytoconstituents reported to inhibit hyaluronidase.
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Date 2021-08-19T05:29:48Z
2021-08-19T05:29:48Z
2019-12-01
 
Type Review Paper
 
Identifier Not Available
2321 – 3663
http://krishi.icar.gov.in/jspui/handle/123456789/58757
 
Language English
 
Relation Not Available;
 
Publisher Scientific Planet Society