Hyaluronidase an enzyme in snake venom and its natural inhibitors: A Review
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Title |
Hyaluronidase an enzyme in snake venom and its natural inhibitors: A Review
Not Available |
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Creator |
Pushpendra Singh, Mohammad Yasir, Ruchi Khare2, Manish Kumar Tripathi, Manoj Kumar Tripathi ,Rahul Shrivastava
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Subject |
Hyaluronidase; Zootoxin; Snake venom; Hyaluronic acid; Spreading factor
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Description |
Not Available
Snakebite causes the highest rate of injury and among the population, especially in Asian countries. Snake venom is a type of zootoxins composed of a highly complex mixture of enzymes including phospholipase A2, hyaluronidase, L-amino acid oxidase, acetylcholine esterase, phosphodiester, and low molecular weight polypeptide. The hyaluronidase or hyaluronic glucosidase venom enzyme is considered a “spreading factor” as it hydrolyzes the hyaluronic acid (generally known as hyaluronan), which plays an essential role of cell to cell adhesion in the extracellular matrix of tissue. Secondary metabolites present in a crude extract of medicinal plants are considered as capable venom neutralizing agents as they have no side effect and can neutralize a wide range of snake venom enzymes. The objective of this review is to collect, simplify and explain the role along with the importance of inhibition of hyaluronic glucosidase in snake venoms. All the accessible information on hyaluronic glucosidases was collected via electronic search (using Google Books, PubMed, SciFinder, Scopus, Google Scholar, and Web of Science) and articles of peer-reviewed journals. This review contains a brief description of the structure, occurrence, mechanism, assay procedures, and phytoconstituents reported to inhibit hyaluronidase. Not Available |
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Date |
2021-08-19T05:29:48Z
2021-08-19T05:29:48Z 2019-12-01 |
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Type |
Review Paper
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Identifier |
Not Available
2321 – 3663 http://krishi.icar.gov.in/jspui/handle/123456789/58757 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Scientific Planet Society
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