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Untranslated regions (UTRs) orchestrate translation reprogramming in cellular stress responses

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Title Untranslated regions (UTRs) orchestrate translation reprogramming in cellular stress responses
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Creator Basavaraj Sajjanara,⁎, Rajib Debb,⁎, Susheel Kumar Rainac, Sachin Pawara, Manoj P. Brahmanea, Avinash V. Nirmalea, Nitin P. Kuradea, Gundallahalli B. Manjunathareddyd, Santanu Kumar Bala, Narendra Pratap Singha
 
Subject Stress responses Translation regulation RNA motifs Stress granules
 
Description Not Available
Stress is the result of an organism's interaction with environmental challenges. Regulations of gene expression
including translation modulations are critical for adaptation and survival under stress. Untranslated regions
(UTRs) of the transcripts play significant roles in translation regulation and continue to raise many intriguing
questions in our understanding of cellular stress physiology. IRES (Internal ribosome entry site) and uORF
(upstream open reading frame) mediated alternative translation initiations are emerging as unique mechanisms.
Recent studies have revealed novel means of mRNAs stabilization in stress granules and their reversible
modifications. Differential regulation of select transcripts is possible by the interplay between the adenine/
uridine-rich elements (AREs) in 3’UTR with their binding proteins (AUBP) and by microRNA-mediated effects.
Coordination of these various mechanisms control translation and thereby enables appropriate responses to
environmental stress. In this review, we focus on the role of sequence signatures both at 5’ and 3’UTRs in
translation reprogramming during cellular stress responses.
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Date 2018-12-01T11:29:16Z
2018-12-01T11:29:16Z
2017-02-16
 
Type Research Paper
 
Identifier Not Available
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http://krishi.icar.gov.in/jspui/handle/123456789/14960
 
Language English
 
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Publisher Not Available