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Molecular diagnostics of human pathogenic Aspergillus species

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Title Molecular diagnostics of human pathogenic Aspergillus species
Not Available
 
Creator Praveen Gehlot
D K Purohit
S K Singh
 
Subject Aspergillus
aspergillosis
genetic markers
RAPD
5.8S rRNA gene sequencing
 
Description Not Available
Eight species of Aspergillus (A. hiratsukae, A. flavus, A. fumigatus, A. terreus, A. niger, A. sydowii, A. clavatus and A. flavipes) were found associated with clinical samples causing human diseases. The nonspecific symptoms and lack of rapid diagnostics is a major problem in treating patients suffering from invasive aspergillosis. Molecular markers based on RAPD primers and diversity in ITS region of 5.8S rRNA gene developed for rapid diagnosis facilitated early treatment of patient
suffering from aspergillosis related disorders. Direct sequencing of amplified ITS products revealed significant single nucleotide polymorphism, which facilitated identification of pathogenic Aspergillus species associated with aspergillosis. The complete sequences of eight Aspergillus species were submitted to NCBI database, USA, which were assigned new Gen accession numbers EU515147 to EU515154 and now available in public domain for comparison.
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Date 2019-05-15T08:58:43Z
2019-05-15T08:58:43Z
2011-01-01
 
Type Research Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/19531
 
Language English
 
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Publisher Not Available