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Comparative study of selenium and selenium nanoparticles with reference to acute toxicity, biochemical attributes, and histopathological response in fish.

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Title Comparative study of selenium and selenium nanoparticles with reference to acute toxicity, biochemical attributes, and histopathological response in fish.
Not Available
 
Creator Neeraj Kumar, Krishnani K.K, Singh NP
 
Subject Selenium . Seleniumnanopartilces . Cellular metabolic stress . Stress biomarkers . Histopathology
 
Description Not Available
Recent studies have demonstrated that selenium (Se) and selenium nanoparticles (Se - NPs) exhibited toxicity at a higher concentration.
The lethal concentration of Se and Se - NPs was estimated as 5.29 and 3.97 mg/L at 96 h in Pangasius hypophthalmus.
However, the effect of different definite concentration of Se (4.5, 5.0, 5.5, and 6.0 mg/L) and Se - NPs (2.5, 3.0, 3.5, and 4.0 mg/L)
was decided for acute experiment. Selenium and Se - NPs alter the biochemical attributes such as anti - oxidative status [catalase
(CAT), superoxide dismutase (SOD), and glutathione - S - transferase (GST) activities], neurotransmitter enzyme, cellular metabolic
enzymes, stress marker, and histopathology of P. hypophthalmus in a dose - and time - dependent manner. CAT, SOD, and
GST were significantly elevated (p < 0.01) when exposed to Se and Se - NPs, and similarly, a neurotransmitter enzyme (acetylcholine
esterase (AChE)) was significantly inhibited in a time - and dose - dependent manner. Further, aspartate aminotransferase,
alanine aminotransferase, lactate dehydrogenase, and malate hydrogenase were noticeably (p < 0.01) affected by Se and Se - NPs
from higher concentration to lower concentration. Stress markers such as cortisol and HSP 70 were drastically enhanced by
exposure to Se and Se - NPs. All the cellular metabolic and stress marker parameters were elevated which might be due to
hyperaccumulation of Se and Se - NPs in the vital organ and target tissues. The histopathology of liver and gill was also altered
such as large vacuole, cloudy swelling, focal necrosis, interstitial edema, necrosis in liver, and thickening of primary lamellae
epithelium and curling of secondary lamellae due to Se and Se - NP exposure. The study suggested that essential trace element in
both forms (inorganic and nano) at higher concentration in acute exposure of Se and Se - NPs led to pronounced deleterious
alteration on histopathology and cellular and metabolic activities of P. hypophthalmus.
Not Available
 
Date 2019-12-08T17:39:48Z
2019-12-08T17:39:48Z
2018-01-01
 
Type Research Paper
 
Identifier 15
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/28777
 
Language English
 
Relation Not Available;
 
Publisher Springer