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Caffeine, a possible suppressor of ultraviolet induced genetic aberrations

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Title Caffeine, a possible suppressor of ultraviolet induced genetic aberrations
Not Available
 
Creator Anjly Pancholy
R. K. Vashishat
 
Subject Caffeine
Genetic
aberrations
ultraviolet
 
Description Not Available
In yeast, the low frequency of spontaneous occurrence of mitotic crossing over is increased several fold by ultraviolet irradiation. Since as a consequence of mitotic crossing over, the genes distal to the crossover become homozygous in fifty per cent of the nuclei resulting in the exposure of defective allels which were otherwise unexperessed due to heterozygous condition of the loci. In the present investigation, inhibition of post-replication repair by 0.1 per cent caffeine greatly reduced (63%) the frequency of UV-induced mitotic crossovers, thereby reducing the chances of occurrence of UV-induced genetic aberrations. Similar studies, if extended to higher systems such as mammalian cells in culture can be of great help in preventing ultraviolet –induced genetic aberrations in humans.
Not Available
 
Date 2020-08-28T11:12:22Z
2020-08-28T11:12:22Z
1995-01-01
 
Type Research Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/40519
 
Language English
 
Relation Not Available;
 
Publisher Not Available