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Secondary metabolism of pharmaceuticals in the plant in vitro cultures: strategies, approaches, and limitations to achieving higher yield
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View Archive Info| Field | Value | |
| Title |
Secondary metabolism of pharmaceuticals in the plant in vitro cultures: strategies, approaches, and limitations to achieving higher yield
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| Creator |
Tasiu Isah, Shahid Umar, Abdul Mujib,Maheshwar Prasad Sharma, P. E. Rajasekharan, Nadia Zafar and Arajmand Frukh
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| Subject |
Medicinal plants · Plant secondary metabolism · Pharmaceuticals · Natural products · Bioactive compounds · Elicitation
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| Description |
Not Available
Biotechnology is playing a vital alternative role in the production of pharmaceutical plant secondary metabolites to support industrial production and mitigate over-exploitation of natural sources. High-value pharmaceuticals that include alkaloids, flavonoids, terpenes, steroids, among others, are biosynthesized as a defensive strategy by plants in response to perturbations under natural environmental conditions. However, they can also be produced using plant cell, tissue, and organ culture techniques through the application of various in vitro approaches and strategies. In the past decades, efforts were on the clonal propagation, biomass and secondary metabolites production in the in vitro cultures of medicinally important plants that produce these molecules. In recent years, the effort has shifted towards optimizing culture conditions for their production through the application of cell line selection, elicitation, precursor feeding, two-phase co-culture among cell, tissue, and organ culture approaches. The efforts are made with the possibility to scale-up the production, meet pharmaceutical industry demand and conserve natural sources of the molecules.Applications of metabolic engineering and production from endophytes are also getting increasing attention but, the approaches are far from practical application in their industrial production. Not Available |
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| Date |
2019-05-25T07:21:29Z
2019-05-25T07:21:29Z 2018-07-11 |
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| Type |
Research Paper
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| Identifier |
Not Available
Not Available http://krishi.icar.gov.in/jspui/handle/123456789/19853 |
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| Language |
English
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| Relation |
Not Available;
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Not Available
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