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Evolutionary and Structural Analyses of Toll-Like Receptors 7 and 8 of Himalayan Kumaon Cattle and Goat

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Title Evolutionary and Structural Analyses of Toll-Like Receptors 7 and 8 of Himalayan Kumaon Cattle and Goat
Not Available
 
Creator Muniswamy Kangayan
Shanmugam ChandraSekar
Barathidasan Rajamani
 
Subject Innate immunity
Toll-like receptor-7
Toll-like receptor-8
Leucine rich repeats
Positive selection
Ligand binding amino acid
Phylogenetic analysis
 
Description Not Available
Toll-like receptors (TLRs) are pattern recognition receptors that are critical for the functions of the host
innate immunity. This study reports complete coding sequences of TLR-7 and TLR-8 of cattle and goat of
Himalayan Kumaon (HK) region. Further, predicted 26 leucine rich repeats (LRRs), two terminal LRR modules
and putative common and differential ligand binding amino acids in TLR-7 and -8 of ruminants. The differential ligand binding amino acids between TLR-7 and TLR-8 of HKcattle were Val396, Arg422, Val513, Asp538 and Val566 in TLR-8; Thr406, Lys432, Thr533, Leu558 and Ile586 in TLR-7. Codon selection analysis revealed co-localization of positively selected codons 377 and 408 of cattle, and 402 and 859 of goat with already reported SNPs in ruminants. The comparative analysis of deduced electrostatic surface potential of the extracellular domain of TLR-7 and -8 resulted in grouping of different species within
ruminants.
Not Available
 
Date 2020-03-09T12:22:06Z
2020-03-09T12:22:06Z
2017-10-26
 
Type Research Paper
 
Identifier Kangayan, M., ChandraSekar, S., Rajamani, B. et al. Evolutionary and Structural Analyses of Toll-Like Receptors 7 and 8 of Himalayan Kumaon Cattle and Goat. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 89, 161–171 (2019). https://doi.org/10.1007/s40011-017-0928-y
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http://krishi.icar.gov.in/jspui/handle/123456789/33705
 
Language English
 
Relation Not Available;
 
Publisher Springer