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Collagen Biosynthesis in Osteoblast Cells Treated with Fish Collagen Peptides

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Title Collagen Biosynthesis in Osteoblast Cells Treated with Fish Collagen Peptides
Not Available
 
Creator Hema, G.S.
Shyni, K.
Manu Prasad, M.
George Ninan
Suseela Mathew
 
Subject Fish collagen peptides
osteoblast cells
collagen quantification
western blotting
immuno-cytochemistry
 
Description Not Available
Collagen is one of the most widely used biomaterials in tissue engineering and regenerative medicine. To
investigate the effect of fish collagen peptides on the formation of collagen proteins by mature osteoblast
cells, human osteoblast cells were treated with collagen peptide in both time and dose dependent manner. The stimulatory effect of collagen peptide was confirmed by western blot and immunocytochemistry analysis. The results clearly indicate that the presence of fish collagen peptides led to a dose dependent increase in collagen synthesis by osteoblast cells upto a concentration of 0.6 mg ml-1. However native collagen or collagen free protein hydrolysate failed to stimulate the production of collagen in osteoblast cells. The results show a stimulatory effect of fish collagen peptides on the collagen biosynthesis in osteoblast cells and suggest a possible mechanism for the regulation of collagen turnover in joint tissues.
Not Available
 
Date 2020-09-23T07:44:50Z
2020-09-23T07:44:50Z
2017-04
 
Type Research Paper
 
Identifier Hema, G.S., Shyni, K., Manu Prasad, M., George Ninan and Suseela Mathew (2017) Collagen biosynthesis in osteblast cells treated with fish collagen peptides, Fish. Technol., 54(2): 107-111
0015-3001
http://krishi.icar.gov.in/jspui/handle/123456789/41538
 
Language English
 
Relation Not Available;
 
Publisher Society of Fisheries Technologists, India