Luteolin-fabricated ZnO nanostructures showed PLK-1 mediated anti-breast cancer activity
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Title |
Luteolin-fabricated ZnO nanostructures showed PLK-1 mediated anti-breast cancer activity
Not Available |
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Creator |
Kollur SP
Prasad SK Pradeep S Veerapur R Patil SS Amachawadi RG Lamraoui G Al-Kheraif AA Elgorban AM Syed A Shivamallu C |
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Subject |
luteolin
ZnONPs in silico analysis PLK1 proteins |
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Description |
Not Available
The present work describes a facile and convenient procedure for synthesizing zinc oxide nanoparticles using luteolin isolated from Eclipta alba plant (L-ZnONPs) at room temperature. The formation of as-grown L ZnONPs was confirmed by X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM), and selected area electron diffraction (SAED). The Wurtzite structure of ZnO was observed by its hexagonal phases in diffraction patterns. The SEM images revealed the different sizes and morphologies of L-ZnONPs, with diameters between 12 and 25 nm. The HR-TEM result showed that the inter-planar distance between two lattice fringes was 0.262 nm, which coincides with the d-spacing of (002) and (101) lattice planes of the as obtained material. The anticancer activity of L-ZnONPs against the breast cancer cell line MCF-7 was greater as compared to that of luteolin or ZnO alone. The mechanistic evaluation of such an activity carried out using in silico methods suggested that the anti-breast cancer activity of L-ZnONPs was mediated by polo-like kinase 1 (PLK1) proteins. Not Available |
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Date |
2021-06-11T03:13:13Z
2021-06-11T03:13:13Z 2021-03-05 |
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Type |
Research Paper
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Identifier |
Kollur SP, Prasad SK, Pradeep S, Veerapur R, Patil SS, Amachawadi RG, Lamraoui G, Al-Kheraif AA, Elgorban AM, Syed A and Shivamallu C. (2021). Luteolin-fabricated ZnO nanostructures showed PLK-1 mediated anti-breast cancer activity. Biomolecules, 11 (3): 385
2218-273X http://krishi.icar.gov.in/jspui/handle/123456789/47229 |
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Language |
English
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Relation |
Not Available;
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Publisher |
MDPI
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