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Luteolin-fabricated ZnO nanostructures showed PLK-1 mediated anti-breast cancer activity

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Title Luteolin-fabricated ZnO nanostructures showed PLK-1 mediated anti-breast cancer activity
Not Available
 
Creator Kollur SP
Prasad SK
Pradeep S
Veerapur R
Patil SS
Amachawadi RG
Lamraoui G
Al-Kheraif AA
Elgorban AM
Syed A
Shivamallu C
 
Subject luteolin
ZnONPs
in silico analysis
PLK1 proteins
 
Description Not Available
The present work describes a facile and convenient procedure for synthesizing zinc oxide nanoparticles using luteolin isolated from Eclipta alba plant (L-ZnONPs) at room temperature. The formation of as-grown L ZnONPs was confirmed by X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM), and selected area electron diffraction (SAED). The Wurtzite structure of ZnO was observed by its hexagonal phases in diffraction patterns. The SEM images revealed the different sizes and morphologies of L-ZnONPs, with diameters between 12 and 25 nm. The HR-TEM result showed that the inter-planar distance between two lattice fringes was 0.262 nm, which coincides with the d-spacing of (002) and (101) lattice planes of the as obtained material. The anticancer activity of L-ZnONPs against the breast cancer cell line MCF-7 was greater as compared to that of luteolin or ZnO alone. The mechanistic evaluation of such an activity carried out using in silico methods suggested that the anti-breast cancer activity of L-ZnONPs was mediated by polo-like kinase 1 (PLK1) proteins.
Not Available
 
Date 2021-06-11T03:13:13Z
2021-06-11T03:13:13Z
2021-03-05
 
Type Research Paper
 
Identifier Kollur SP, Prasad SK, Pradeep S, Veerapur R, Patil SS, Amachawadi RG, Lamraoui G, Al-Kheraif AA, Elgorban AM, Syed A and Shivamallu C. (2021). Luteolin-fabricated ZnO nanostructures showed PLK-1 mediated anti-breast cancer activity. Biomolecules, 11 (3): 385
2218-273X
http://krishi.icar.gov.in/jspui/handle/123456789/47229
 
Language English
 
Relation Not Available;
 
Publisher MDPI