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Pathological and molecular investigations of systemic form of camelpox in naturally infected adult male dromedary camels in India

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Title Pathological and molecular investigations of systemic form of camelpox in naturally infected adult male dromedary camels in India
Not Available
 
Creator Shirish Dadarao Narnaware,
Rakesh Ranjan,
Shyam Singh Dahiya,
Amar Panchbuddhe,
Devika Bajpai,
Fateh Chand Tuteja,
 
Subject Camelpox
Histopathology
Mortality
Pathology
PCR
Systemic form
 
Description Not Available
Camelpox is a wide-spread infectious viral disease of camelids. An outbreak of camelpox was reported in 15 adult male dromedary camels aged between 10 to 16 years of an organized herd in winter season. The infected camels showed clinical signs of fever, anorexia, lachrymation, pendulous lips, excessive salivation and pock lesions on the skin of head, neck, mouth, lips, extremities, thigh, abdomen, scrotum and inguinal region. Mortalities were recorded in three infected camels after 10–12 days of infection and showed systemic pox lesions characterized by vesicles, papules, ulcerations and raised pock lesions in the mucous membranes of the mouth, tongue, tracheal mucosa, lung, abomasum and liver. Histopathology study revealed characteristic pox lesions with intracytoplasmic eosinophilic inclusion bodies in tongue. Lung showed lesion of interstitial pneumonia (n ¼ 2) and bronchointerstitial pneumonia (n ¼ 1). Liver showed infiltration of mononuclear cells around central veins and degenerative changes of hepatocytes. The abomasum and intestine showed ulcerations, marked capillary congestion and areas of lymphocyte infiltration in mucosa and submucosa. The presence of camelpox virus (CMLV) was confirmed in viral DNA isolated from formalin fixed paraffin embedded (FFPE) tissues of tongue, lung, abomasum, liver, heart and intestine of infected camels by C18L gene PCR. The sequencing of viral DNAs showed phylogenetic relatedness with other CMLV isolates from India and other countries. Thus, our study confirmed the rare severe form of systemic camelpox outbreak in adult male dromedary camels hence future attention should be given for studies on virulence, strain identification and molecular epidemiology of CMLV for planning of effective preventive and control strategies.
Not Available
 
Date 2021-06-17T06:40:50Z
2021-06-17T06:40:50Z
2021-01-31
 
Type Article
 
Identifier Not Available
2405-8440
http://krishi.icar.gov.in/jspui/handle/123456789/47331
 
Language English
 
Relation Not Available;
 
Publisher Elsevier