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Short communication: preliminary observations on the serum levels of HSP70 and its correlation with serum cortisol, thyroid hormones, and acute-phase protein concentration in cattle naturally infected with foot-and-mouth disease virus

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Title Short communication: preliminary observations on the serum levels of HSP70 and its correlation with serum cortisol, thyroid hormones, and acute-phase protein concentration in cattle naturally infected with foot-and-mouth disease virus
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Creator Smrutirekha Mallick, Saravanan Subramaniam, Jitendra Kumar Biswal, Rajeev Ranjan, Jajati Keshari Mohapatra, Aditya Prasad Sahooot Available
 
Subject Acute-phase proteins; Cortisol; Foot-and-mouth disease; Serum HSP70; Thyroid hormone.
 
Description Not Available
The study aimed to explore the serum levels of HSP70 and identify its possible association with serum cortisol, thyroid hormones, and acute-phase protein concentrations in cattle naturally infected with foot-and-mouth disease (FMD) virus. After the FMD outbreak in an organized dairy cattle farm in India, blood samples were obtained from clinically infected (n = 40) and apparently healthy (n = 30) animals. Samples were processed and tested by an in-house DIVA assay for confirmation of FMD infection. Serum was analyzed for HSP70, cortisol, T4, T3, haptoglobin, and serum amyloid A by enzyme-linked immunosorbent assay (ELISA). HSP70 concentrations were significantly higher in the serum of clinically infected cattle (p < 0.01) than the healthy group. To the best of our knowledge, this is the first report describing the elevated serum levels of HSP70 under infectious diseases of bovines. Cortisol (p < 0.05), haptoglobin (p < 0.001), and serum amyloid A (p < 0.05) concentrations also markedly increased in the diseased animals; however, no differences (p > 0.05) were found in T4 and T3 levels between healthy and infected cattle. Elevated HSP70 concentration correlated positively with high cortisol (p < 0.05) and haptoglobin (p < 0.001) levels suggesting an essential link between these acute events during clinical infectious phase of FMD.
ICAR-Directorate of Foot and Mouth Disease
 
Date 2021-07-30T05:39:51Z
2021-07-30T05:39:51Z
2021-07-25
 
Type Research Paper
 
Identifier Mallick S., Subramaniam S., Biswal J K., Ranjan R., Mohapatra J K. and Sahoo A P. Trop Anim Health Prod . 2021 Jul 22;53(4):408.
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http://krishi.icar.gov.in/jspui/handle/123456789/51395
 
Language English
 
Relation Not Available;
 
Publisher SPRINGER