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Comparative evaluation of allergic sensitization to milk proteins of cow, buffalo and goat.

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Title Comparative evaluation of allergic sensitization to milk proteins of cow, buffalo and goat.
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Creator Kapila, R.*, Kavadi, P.K. and Kapila, S.
 
Subject Allergy
Milk proteins
Cow
Buffalo
 
Description Not Available
Milk hypersensitivity due to adverse reactions to milk proteins is among the major public concern of food allergies. In present investigation, comparative assessment of humoral and cell mediated immune responses in mice associated with allergenicity of major milk proteins (casein and β-lactoglobulin) of cow, buffalo and goat were carried out. Caseins of all three species of dairy animals appeared to be less immunogenic and allergenic than their corresponding β-lactoglobulins. Cow milk proteins (caseins and β-lactoglobulin) were observed to increase protein specific IgE sensitization as well as lymphocyte proliferation index significantly (P < 0.01) as compared to buffalo and goat milk proteins. On the other hand, buffalo and goat milk proteins similar to cow's proteins raised remarkably higher (P < 0.01) immunogenic response in terms of IgG levels than the negative control group. The results obtained were correlated with B and T cell epitopes of milk proteins cited in literature after multiple alignment in silico. Thus present study suggests cow milk proteins (β-lactoglobulin and casein) are highly allergenic among the milk proteins of three species of dairy animals.
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Date 2021-07-31T09:21:41Z
2021-07-31T09:21:41Z
1001-01-01
 
Type Research Paper
 
Identifier Kapila, R.*, Kavadi, P.K. and Kapila, S.(2013). Comparative evaluation of allergic sensitization to milk proteins of cow, buffalo and goat. Small Ruminant Research 112: 191– 198.ilable
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http://krishi.icar.gov.in/jspui/handle/123456789/51660
 
Language English
 
Relation 112;
 
Publisher Elsevier