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Comparative genome analysis of short sequence repeats in pathogenic and non pathogenic leptospira- a statistical approach

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Title Comparative genome analysis of short sequence repeats in pathogenic and non pathogenic leptospira- a statistical approach
Not Available
 
Creator Indumathi K
Sunil A
Ramasamy V
Asir A
Santra S
Rahman H
Gorti RK
Suresh KP
 
Subject Short sequence repeats
Leptospira
Chromosome I and II
microsatellites
Statistical analysis
 
Description Not Available
Leptospira is a pathogenic bacteria, which causes Leptospirosis in humans and animals. The genome sequence of Leptospira interrogans Lai (Pathogenic) and
Leptospira biflexa Patoc (Non-Pathogenic) were retrieved and examined for the presence of Short Sequence Repeats (SSR) (n=1,2,3)in Chromosome I and Chromosome II.
SSRs or microsatellites extensively exist in genomes of prokaryotes and eukaryotes. Simple sequence repeats are the genetic loci where the bases are tandemly repeated for
varying number of times. Comparative genome analysis will provide a better understanding in the identification of the evolutionary relationship between pathogenic and nonpathogenic
species. SSRs in genome sequences (pathogenic and non- pathogenic) were found using ‘R’ script, which was implemented in R packages. It was observed that the
pathogenic sequence contains a number of tandem repeats in both the chromosomes. Meanwhile, the occurrence of C/G or G/C has more difference in their frequencies between
pathogenic and non-pathogenic sequences. In both the chromosomes, dinucleotide repeats are frequent, but in the case of TC in both the chromosomes and GA in chromosome II
are found to be less significant. Additionally, trinucleotide repeats are longer in pathogenic, whereas in non-pathogenic they are shorter. The statistical analysis of the microsatellites
in both the sequences indicates the highly significant pattern of nucleotide repeats. The more number of genes in the pathogenic species may be acquired to the virulence in their
course of evolution. This work partially suggests that SSRs plays a major role in genetic diversity, gene evolution and also in understanding the genomic instability
Not Available
 
Date 2018-11-06T03:26:03Z
2018-11-06T03:26:03Z
2016-01-01
 
Type Research Paper
 
Identifier Not Available
0975-2862
http://krishi.icar.gov.in/jspui/handle/123456789/9419
 
Language English
 
Relation Not Available;
 
Publisher Bioinfo publications