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Evolution and Spread of Avian Influenza H5N1 Viruses

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Title Evolution and Spread of Avian Influenza H5N1 Viruses
Not Available
 
Creator Tosh C.
Nagarajan S.
Murugkar H.V.
Bhatia S.
Kulkarni D.D.
 
Subject Influenza
Influenza A Virus
Avian
Hemagglutinin
NA protein
M2 protein
Molecular Evolution
Phylogeny
Virology
Influenza Vaccines
Adamantane
Oseltamivir
Research
 
Description Not Available
An outbreak of highly pathogenic avian influenza A (H5N1) has recently spread to poultry in 9 Asian countries. H5N1 infections have caused >52 human deaths in Vietnam, Thailand, and Cambodia from January 2004 to April 2005. Genomic analyses of H5N1 isolates from birds and humans showed 2 distinct clades with a nonoverlapping geographic distribution. All the viral genes were of avian influenza origin, which indicates absence of reassortment with human influenza viruses. All human H5N1 isolates tested belonged to a single clade and were resistant to the adamantane drugs but sensitive to neuraminidase inhibitors. Most H5N1 isolates from humans were antigenically homogeneous and distinct from avian viruses circulating before the end of 2003. Some 2005 isolates showed evidence of antigenic drift. An updated nonpathogenic H5N1 reference virus, lacking the polybasic cleavage site in the hemagglutinin gene, was produced by reverse genetics in anticipation of the possible need to vaccinate humans.
Not Available
 
Date 2018-03-22T07:50:14Z
2018-03-22T07:50:14Z
2014-05-01
 
Type Research Paper
 
Identifier Tosh C, Nagarajan S, Murugkar HV, Bhatia S, Kulkarni DD (2014). Evolution and Spread of Avian Influenza H5N1 Viruses. Advances in Animal and Veterinary Sciences 2 (4S): 33 – 41. (Review article).
2307-8316
http://krishi.icar.gov.in/jspui/handle/123456789/5985
 
Language English
 
Relation Not Available;
 
Publisher Nexus academic Publishers