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Low prevalence of CCR5-Δ32, CCR2-64I and SDF1-3'Aalleles in the Baiga and Gond tribes of Central India.

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Title Low prevalence of CCR5-Δ32, CCR2-64I and SDF1-3'Aalleles in the Baiga and Gond tribes of Central India.
Not Available
 
Creator Bharti D.
Kumar A.
Mahla R.S.
Kumar S.
Ingle H.
Yadav T.
Mishra A.
Raut A.A.
Kumar H.
 
Subject Primitive tribes
Non-primitive tribes
Chemokine receptors
HIV-1 resistant polymorphisms
Relative hazard
 
Description Not Available
Human immunodeficiency virus-1 (HIV-1) which causes acquired immune deficiency syndrome (AIDS), by infecting CD4+ immune cells and hence weakening the host defense mechanism till death, is one of the major factor responsible for human demises worldwide. Both innate (monocytes and macrophages) and adaptive (T cells) immune cells expresses chemokines receptors (2 and 5) and stromal cell derived factor-1 (SDF-1) which play crucial role in HIV-1 virus entry and progression. Allele variants of genes CCR5 (CCR5-Δ32), CCR2 (CCR2-64I) and SDF1 (SDFA-3′A; the ligand of CXCR4) are known to slow down the HIV-1 progression in infected individual. In the present study, the frequency of CCR5-Δ32, CCR2-64I and SDF1-3′A alleles in primitive tribe (Baiga) and a non-primitive tribe (Gond) of central India were investigated. A total 200 seronegative samples for HIV from healthy individuals of tribes were analyzed and observed allele frequencies of CCR5-Δ32, CCR2-64I and SDF1-3′A were (0, 0.035, 0.080) and (0, 0.110, 0.100) in Baiga and Gond respectively. Minor allele frequency of these alleles of Gond and Baiga tribes were compared with different populations of the world for relative hazard (RH), which indicate the risk of progression after infection of HIV1. The RH values were calculated based on genotypic frequency, showed the high RH value (RH1-AIDS1993-0.98, RH2-AIDS1987-0.98 and death/RH3-0.97) in Baiga tribe, indicates the low level of resistance against HIV-1 progression after infection.
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Date 2018-03-22T07:52:27Z
2018-03-22T07:52:27Z
2015-08-01
 
Type Research Paper
 
Identifier Bharti D, Kumar A, Mahla RS, Kumar S, Ingle H, Yadav T, Mishra A, Raut AA and Kumar H. (2015). Low prevalence of CCR5-Δ32, CCR2-64I and SDF1-3'Aalleles in the Baiga and Gond tribes of Central India. Springerplus. Springerplus. 2015 Aug 25;4:451.
2193-1801
http://krishi.icar.gov.in/jspui/handle/123456789/6002
 
Language English
 
Relation Not Available;
 
Publisher Springer International Publishing