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Genome Wide Host Gene Expression Analysis in Chicken Lungs Infected with Avian Influenza Viruses.

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Title Genome Wide Host Gene Expression Analysis in Chicken Lungs Infected with Avian Influenza Viruses.
Not Available
 
Creator Ranaware P.B.
Mishra A.
Vijayakumar P.
Gandhale P.N.
Kumar H.
Kulkarni D.D.
Raut A.A.
 
Subject Molecular pathogenesis
LPAIV
CX3CL1
Dysregulation
HPAIV
 
Description Not Available
The molecular pathogenesis of avian influenza infection varies greatly with individual bird species and virus strain. The molecular pathogenesis of the highly pathogenic avian influenza virus (HPAIV) or the low pathogenic avian influenza virus (LPAIV) infection in avian species remains poorly understood. Thus, global immune response of chickens infected with HPAI H5N1 (A/duck/India/02CA10/2011) and LPAI H9N2 (A/duck/India/249800/2010) viruses was studied using microarray to identify crucial host genetic components responsive to these infection. HPAI H5N1 virus induced excessive expression of type I IFNs (IFNA and IFNG), cytokines (IL1B, IL18, IL22, IL13, and IL12B), chemokines (CCL4, CCL19, CCL10, and CX3CL1) and IFN stimulated genes (OASL, MX1, RSAD2, IFITM5, IFIT5, GBP 1, and EIF2AK) in lung tissues. This dysregulation of host innate immune genes may be the critical determinant of the severity and the outcome of the influenza infection in chickens. In contrast, the expression levels of most of these genes was not induced in the lungs of LPAI H9N2 virus infected chickens. This study indicated the relationship between host immune genes and their roles in pathogenesis of HPAIV infection in chickens.
Not Available
 
Date 2018-03-22T07:54:13Z
2018-03-22T07:54:13Z
2016-04-01
 
Type Research Paper
 
Identifier Ranaware PB, Mishra A, Vijayakumar P, Gandhale PN, Kumar H, Kulkarni DD, Raut AA. Genome Wide Host Gene Expression Analysis in Chicken Lungs Infected with Avian Influenza Viruses.PLoS One. 2016 Apr 12;11(4):e0153671.
1932-6203
http://krishi.icar.gov.in/jspui/handle/123456789/6015
 
Language English
 
Relation Not Available;
 
Publisher Public Library of Science