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Comparative expression profile of NOD1/2 and certain acute inflammatory cytokines in thermal-stressed cell culture model of native and crossbred cattle

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Title Comparative expression profile of NOD1/2 and certain acute inflammatory cytokines in thermal-stressed cell culture model of native and crossbred cattle
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Creator Bhanuprakash V, Singh U, Sengar GS, Raja TV, Sajjanar B, Alex R, Kumar S, Alyethodi RR, Kumar A, Sharma A, Kumar S, Bhusan B, Deb R
 
Subject Not Available
 
Description Not Available
Thermotolerance depends mainly on the health and immune status of the animals. The variation in the immune status of the animals may alter the level of tolerance of animals exposed to heat or cold stress. The present study was conducted to investigate the expression profile of two important nucleotide binding and oligomerization domain receptors (NLRs) (NOD1 and NOD2) and their central signalling molecule RIP2 gene during in vitro thermal-stressed bovine peripheral blood mononuclear cells (PBMCs) of native (Sahiwal) and crossbred (Sahiwal X HF) cattle. We also examined the differential expression profile of certain acute inflammatory cytokines in in vitro thermal-stressed PBMC culture among native and its crossbred counterparts. Results revealed that the expression profile of NOD1/2 positively correlates with the thermal stress, signalling molecule and cytokines. Present findings also highlighted that the expression patterns during thermal stress were comparatively superior among indigenous compared to crossbred cattle which may add references regarding the better immune adaptability of Zebu cattle
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Date 2017-07-01T04:56:41Z
2017-07-01T04:56:41Z
2017-05-01
 
Type Research Paper
 
Identifier 01
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http://krishi.icar.gov.in/jspui/handle/123456789/4563
 
Language English
 
Relation Not Available;
 
Publisher Springer