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Aryl-alkyl-lysines: Agents that kill planktonic cells, persister cells, biofilms of MRSA and protect mice from skin-infection

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Title Aryl-alkyl-lysines: Agents that kill planktonic cells, persister cells, biofilms of MRSA and protect mice from skin-infection
Not Available
 
Creator Ghosh C
Goutham B M
Mohini K M
Uppu D S S
Krishnamoorthy P
Shome B R
Haldar J
 
Subject Arly Akyl Lysines, Mice, Skin Infections, MRSA
 
Description Not Available
Development of synthetic strategies to combat Staphylococcal infections, especially those
caused by methicillin resistant Staphyloccus aureus (MRSA), needs immediate attention. In
this manuscript we report the ability of aryl-alkyl-lysines, simple membrane active small molecules,
to treat infections caused by planktonic cells, persister cells and biofilms of MRSA.
A representative compound, NCK-10, did not induce development of resistance in planktonic
cells in multiple passages and retained activity in varying environments of pH and
salinity. At low concentrations the compound was able to depolarize and permeabilize the
membranes of S. aureus persister cells rapidly. Treatment with the compound not only eradicated
pre-formed MRSA biofilms, but also brought down viable counts in bacterial biofilms.
In a murine model of MRSA skin infection, the compound was more effective than fusidic
acid in bringing down the bacterial burden. Overall, this class of molecules bears potential
as antibacterial agents against skin-infections.
Not Available
 
Date 2018-09-15T07:09:16Z
2018-09-15T07:09:16Z
2015-12-15
 
Type Research Paper
 
Identifier Ghosh C, Manjunath GB, Konai MM, Uppu DSSM, Hoque J, Paramanandham K, et al. (2015) Aryl-Alkyl-Lysines: Agents That Kill Planktonic Cells, Persister Cells, Biofilms of MRSA and Protect Mice from Skin-Infection. PLoS ONE 10(12): e0144094. doi:10.1371/journal.pone.0144094
1932-6203
http://krishi.icar.gov.in/jspui/handle/123456789/6894
 
Language English
 
Relation Not Available;
 
Publisher Public Library of Science