Aryl-alkyl-lysines: Agents that kill planktonic cells, persister cells, biofilms of MRSA and protect mice from skin-infection
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Title |
Aryl-alkyl-lysines: Agents that kill planktonic cells, persister cells, biofilms of MRSA and protect mice from skin-infection
Not Available |
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Creator |
Ghosh C
Goutham B M Mohini K M Uppu D S S Krishnamoorthy P Shome B R Haldar J |
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Subject |
Arly Akyl Lysines, Mice, Skin Infections, MRSA
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Description |
Not Available
Development of synthetic strategies to combat Staphylococcal infections, especially those caused by methicillin resistant Staphyloccus aureus (MRSA), needs immediate attention. In this manuscript we report the ability of aryl-alkyl-lysines, simple membrane active small molecules, to treat infections caused by planktonic cells, persister cells and biofilms of MRSA. A representative compound, NCK-10, did not induce development of resistance in planktonic cells in multiple passages and retained activity in varying environments of pH and salinity. At low concentrations the compound was able to depolarize and permeabilize the membranes of S. aureus persister cells rapidly. Treatment with the compound not only eradicated pre-formed MRSA biofilms, but also brought down viable counts in bacterial biofilms. In a murine model of MRSA skin infection, the compound was more effective than fusidic acid in bringing down the bacterial burden. Overall, this class of molecules bears potential as antibacterial agents against skin-infections. Not Available |
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Date |
2018-09-15T07:09:16Z
2018-09-15T07:09:16Z 2015-12-15 |
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Type |
Research Paper
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Identifier |
Ghosh C, Manjunath GB, Konai MM, Uppu DSSM, Hoque J, Paramanandham K, et al. (2015) Aryl-Alkyl-Lysines: Agents That Kill Planktonic Cells, Persister Cells, Biofilms of MRSA and Protect Mice from Skin-Infection. PLoS ONE 10(12): e0144094. doi:10.1371/journal.pone.0144094
1932-6203 http://krishi.icar.gov.in/jspui/handle/123456789/6894 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Public Library of Science
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