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Effect of subchronic fluoride exposure on immune status and histopathology in rats and its ameliorative measures

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Title Effect of subchronic fluoride exposure on immune status and histopathology in rats and its ameliorative measures
Not Available
 
Creator Krishnamoorthy P
Gowda NKS
Vallesha NC
Rajendran D
Maya G
Verma S
Rahman H
 
Subject Aluminium silicate; Boron; Calcium chloride; Fluoride toxicity; Immunity; Histopathology; Wistar albino rat
 
Description Not Available
The aim of the present investigation was to study the effects of fluorideinduced
toxicity in rats on immunity and histopathology and its possible amelioration
with boron, calcium chloride, and aluminium silicate. Sixty-four male Wistar albino
rats, aged 8 to 12 weeks, were divided into eight groups of eight rats each. The control
group, A, was given normal water while the treatment groups, B, C, D, E, F, G, and H,
were given 30 ppm fluoride ion (F), 30 ppm F with 50 ppm boron, 50 ppm boron, 30
ppm F with 50 ppm calcium chloride, 50 ppm calcium chloride, 30 ppm F with 50 ppm
aluminium silicate, and 50 ppm aluminium silicate, respectively. After four months,
the rats were sacrificed, and blood and tissues collected for immune and
histopathological studies, respectively. The effect on humoral and cell-mediated
immunity was assessed by the antibody titre against sheep red blood cells and the
lymphocyte proliferation assay, respectively. There was a significant decrease in cellmediated
immunity in rats given F alone and F in combination with aluminium
silicate. Histopathological changes due to F toxicity were observed in the liver with
vacuolar degeneration and hepatocellular necrosis, in the kidney with tubular casts,
in the thyroid with loss of colloid with degeneration of epithelial cells, in the thymus
with loss of lymphocytes and plasma cells, and in the spleen with loss of
lymphocytes. These histopathological changes were ameliorated by
supplementation with boron and calcium chloride, but not with aluminium silicate.
Thus, both boron and calcium chloride, at 50 ppm, may effectively ameliorate F
toxicity in the rat.
Not Available
 
Date 2018-09-15T07:08:54Z
2018-09-15T07:08:54Z
2015-06-30
 
Type Research Paper
 
Identifier Not Available
2253-4083
http://krishi.icar.gov.in/jspui/handle/123456789/6892
 
Language English
 
Relation Not Available;
 
Publisher International Society for Fluoride Research