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In-vivo efficacy and pharmacological properties of a novel glycopeptide (YV4465) against vancomycin-intermediate Staphylococcus aureus

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Title In-vivo efficacy and pharmacological properties of a novel glycopeptide (YV4465) against vancomycin-intermediate Staphylococcus aureus
Not Available
 
Creator Venkateswarlu Y
Mohini MK
Krishnamoorthy P
Nimita CV
Shome BR
Haldar J
 
Subject Antibiotic resistance, Glycopeptide antibiotics, Vancomycin, Vancomycin-resistant bacteria, In vivo antibacterial activity
 
Description Not Available
Infections caused by vancomycin-intermediate Staphylococcus aureus (VISA) are associated with high rates of vancomycin treatment failure. The lipophilic vancomycin–carbohydrate conjugate YV4465 is a new glycopeptide antibiotic that is active against a variety of clinically relevant multidrug-resistant Gram-positive pathogens in vitro. YV4465 was 50- and 1000-fold more effective than vancomycin against VISA and vancomycin-resistant enterococci, respectively. This study evaluated the in vivo efficacy against VISA as well as the pharmacokinetics and toxicology of YV4465. A neutropenic mouse thigh infection model was used for the determination of efficacy and pharmacodynamic properties against VISA. YV4465 produced a dose-dependent reduction in VISA titres in thigh muscle; bacterial titres were reduced by up to ca. 2 log10 CFU/g from the pre-treatment titre at a dosage of 8 mg/kg. Single-dose pharmacokinetic studies demonstrated an increase in drug exposure to the animal following linear kinetics with a prolonged half-life (t1/2) compared with vancomycin. The peak plasma concentration (Cmax) following an intravenous dose of 12 mg/kg was 703 μg/mL. Acute toxicology studies revealed that YV4465 did not cause any significant alterations in biochemical parameters related to major organs such as the liver and kidneys at its pharmacodynamic endpoint (>ED2-log kill). These studies demonstrate that YV4465 has the potential to be developed as a next-generation glycopeptide antibiotic for the treatment of infections caused by VISA.
Not Available
 
Date 2018-09-15T07:07:20Z
2018-09-15T07:07:20Z
2015-06-24
 
Type Research Paper
 
Identifier Not Available
0924-8579
http://krishi.icar.gov.in/jspui/handle/123456789/6886
 
Language English
 
Relation Not Available;
 
Publisher Elsevier Publications