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Boron influences immune and antioxidant responses by modulating hepatic superoxide dismutase activity under calcium deficit abiotic stress in Wistar rats

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Title Boron influences immune and antioxidant responses by modulating hepatic superoxide dismutase activity under calcium deficit abiotic stress in Wistar rats
Not Available
 
Creator Bhasker TV
Gowda NKS
Mondal S
Krishnamoorthy P
Pal DT
Mor A
Bhat SK
Pattanaik AK
 
Subject Antioxidant Boron Immunity Superoxide dismutase
 
Description Not Available
The influence of Boron (B) supplementation on immune and antioxidant status of rats with or without
abiotic stress induced by dietary calcium (Ca) restriction was studied in a feeding trial of 90 days. Wistar
strain rats (3–4 wk age, n = 84) were divided into 7 dietary groups (4 replicates of 3 each) viz., normalcalcium
(100%) basal diet alone (NC, control) or supplemented with B at 5 (NCB-5), 10 (NCB-10), 20
(NCB-20) and 40 ppm (NCB-40) levels; low-calcium (50%) basal diet alone (LC) or supplemented with
40 ppm B (LCB-40). After 75 days of experimental feeding, rats were challenged with intraperitoneal
injection of sheep RBCs to assess their humoral immunity. At the end of the trial, cell-mediated immunity
was assessed as foot pad reaction to sheep RBCs injected into the hind leg paws. Eight rats from each
group were sacrificed to collect blood for estimation of minerals and total antioxidant activity, and liver
for superoxide dismutase gene expression analysis. Supplementation of graded levels of B (5, 10, 20 and
40 ppm) as borax in NC diets significantly increased (P < 0.01) the footpad thickness and serum total
antioxidant activity, hepatic expression levels of both Cu-Zn SOD (SOD1) and Mn-SOD (SOD2) mRNAs.
The erythrocytic SOD activity and humoral response did not differ significantly among the dietary groups.
In Ca restricted groups, humoral immune response was significantly decreased (P < 0.01) compared to
control but increased (P < 0.05) with 40 ppm B supplementation. Serum levels of copper (Cu) and zinc
(Zn) remained similar among the dietary groups, while the manganese (Mn) content was significantly
decreased (P < 0.01) with increased levels of dietary B. In conclusion, B supplementation increased the
hepatic mRNA expression levels of both SOD isoenzymes,thereby improving the immune and antioxidant
status.
Not Available
 
Date 2018-09-15T09:30:28Z
2018-09-15T09:30:28Z
2016-04-12
 
Type Research Paper
 
Identifier Not Available
0946-672X
http://krishi.icar.gov.in/jspui/handle/123456789/6907
 
Language English
 
Relation Not Available;
 
Publisher Elsevier Publications