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Emergence of novel reassortant H6N2 avian influenza viruses in ducks in India.

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Title Emergence of novel reassortant H6N2 avian influenza viruses in ducks in India.
Not Available
 
Creator Kumar, M.
Nagarajan, S.
Murugkar, H. V.
Saikia, B.
Singh, B.,
Mishra, A.
Tripathi, S. K.
Agarwal, S.
Shukla, S.
Kulkarni, D. D.
Singh, V.P.
Tosh, C.
 
Subject Ducks; H6N2 subtype; India; Low pathogenic avian influenza virus; Phylogenetic analysis; Reassortment.
 
Description Not Available
The recent reports of human infection due to H6 subtype avian influenza viruses (AIV), which are prevalent in terrestrial poultry, indicate evolution of the virus to a possible pandemic strain. Here, we report antigenic and genetic characterization of two H6N2 viruses isolated from apparently healthy domestic ducks in Kerala and Assam, India during 2014 and 2015, respectively. Hemagglutination inhibition assay revealed antigenic divergence between the two isolates, which was corroborated by amino acid differences at 55 positions (15.98%) between their hemagglutinin (HA) 1.The sequence analyses indicated that both the viruses are avian origin with avian receptor specificity, low pathogenic to poultry and sensitive to oseltamivir. However, Kerala14 had V27I mutation marker for amantadine resistance in M2. The Assam15 virus had an additional N-linked glycosylation on HA2 (position 557) compared to Kerala14 virus. Phylogenetic analysis of the HA gene revealed that both the viruses belonged to distinct lineages (Eurasian and Asia II). Phylogeny of neuraminidase and internal gene segments revealed that both the viruses are novel reassortants and are genetically distinct with different gene constellations. The results suggest independent introductions of the two H6N2 viruses into India and migratory wild birds in the Central Asian flyway might be the source of H6N2 viruses in ducks in India. Therefore, continued AIV surveillance in poultry and wild birds is essential for early detection of emergence of novel strains with pandemic potential and control of their spread.
Not Available
 
Date 2018-09-27T08:20:05Z
2018-09-27T08:20:05Z
2018-07-01
 
Type Journal
 
Identifier Kumar, M., Nagarajan, S., Murugkar, H. V., Saikia, B., Singh, B., Mishra, A., Tripathi, S. K., Agarwal, S., Shukla, S., Kulkarni, D. D., Singh, V.P. and Tosh, C. 2018. Emergence of novel reassortant H6N2 avian influenza viruses in ducks in India. Infection Genetics and Evolution, 61: 20-23.
29530659
http://krishi.icar.gov.in/jspui/handle/123456789/7305
 
Language English
 
Relation Not Available;
 
Publisher Elsevier Publications