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Comprehensive Approaches for Diagnosis of Human Brucellosis

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Title Comprehensive Approaches for Diagnosis of Human Brucellosis
Not Available
 
Creator Shome R
Narayana Rao K
Nagalingam M
Krishnamoorthy P
Krithiga N
Padmashree BS
Triveni K
Shome BR
 
Subject Brucellosis
Risk group
Isolation
Serology
peR
 
Description Not Available
Brucellosis is both occupational and non-occupational infectious disease which occurs due to contact with infected animals and contaminated animal products. The disease is invariably under-diagnosed, likely because of misleading clinical presentation. Hence, timely and accurate diagnosis is essential for prompt treatment and faster recovery of the patient. To enableanearly and accurate Brucella detection, cultural, serological and molecular diagnostic techniques were carried out. Out of 219 serum samples, 75.3% and 24.7% were males and females respectively, 66, 99 and 54 were veterinary professionals, animal handlers and other suspected cases, respectively. In different diagnostic tests that were employed, 53 (24.20%), 32 (14.61%), 14 (6.39%) and 4 (1.83%) were positive by IgGELISA, RBPT, PCR and IgM ELISA respectively, in the descending order of positivity. Out of 32 RBPT positive samples, 18 (56.25%) samples showed significant titres by STAT. From the same RBPT positive samples, B. abortus and B. melitensis were isolated and confirmed by bacteriological and species specific PCR. The high number of seropositives was detected in male and veterinary professionals which confirms brucellosis as a major public health concern in risk group and combination of tests such as RBPT, STAT, ELISA and PCR are essentially required to have a foolproof diagnosis.
Not Available
 
Date 2018-11-01T03:28:20Z
2018-11-01T03:28:20Z
2013-01-01
 
Type Research Paper
 
Identifier Not Available
0970-9320
http://krishi.icar.gov.in/jspui/handle/123456789/8860
 
Language English
 
Relation Not Available;
 
Publisher Indian Society for Veterinary Microbiologists, Immunologists and Specialists of Infectious diseases