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Streptococcus uberis ST439 and ST475 induce differential inflammatory responses in a mouse intramammary infection model

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Title Streptococcus uberis ST439 and ST475 induce differential inflammatory responses in a mouse intramammary infection model
Not Available
 
Creator Mitra SD
Shome BR
Bhuvana M
Velu D
Banerjee A
Bankar K
Ghosh SK
Santra S
Suresh KP
Rahman H
 
Subject Immune response
Mastitis
Mice model
S. uberis
 
Description Not Available
Streptococcus uberis causing mastitis is a growing challenge to the dairy industry. Molecular, epidemiological and population structure studies have revealed clonal diversity among the infecting strains. In this study, mouse intramammary infection model was used to uncover the host immune response to two epidemiologically important live strains of S. uberis (SU1and SU2) obtained from subclinical case of mastitis possessing specific and unique multi locus sequence types (ST), pulsed field gel electrophoresis (PFGE) pulsotypes and virulence profiles. Temporal (2h, 4h, 8h, 12h, 24h and 48h) expression of key inflammatory mediators (IL2, IL4, IL6, IL12, TNFα, IFNγ, GMCSF, TLR2, TLR4, TLR9, TLR11, TLR12, CD14, IL1β, RANTES, Lactoferrin, and CXCl1) by reverse transcription and probe-based quantitative real-time PCR showed relative mRNA levels higher (p
Not Available
 
Date 2018-11-05T03:47:03Z
2018-11-05T03:47:03Z
2016-07-10
 
Type Research Paper
 
Identifier Not Available
1596-5996
http://krishi.icar.gov.in/jspui/handle/123456789/9273
 
Language English
 
Relation Not Available;
 
Publisher Elsevier