Streptococcus uberis ST439 and ST475 induce differential inflammatory responses in a mouse intramammary infection model
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Title |
Streptococcus uberis ST439 and ST475 induce differential inflammatory responses in a mouse intramammary infection model
Not Available |
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Creator |
Mitra SD
Shome BR Bhuvana M Velu D Banerjee A Bankar K Ghosh SK Santra S Suresh KP Rahman H |
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Subject |
Immune response
Mastitis Mice model S. uberis |
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Description |
Not Available
Streptococcus uberis causing mastitis is a growing challenge to the dairy industry. Molecular, epidemiological and population structure studies have revealed clonal diversity among the infecting strains. In this study, mouse intramammary infection model was used to uncover the host immune response to two epidemiologically important live strains of S. uberis (SU1and SU2) obtained from subclinical case of mastitis possessing specific and unique multi locus sequence types (ST), pulsed field gel electrophoresis (PFGE) pulsotypes and virulence profiles. Temporal (2h, 4h, 8h, 12h, 24h and 48h) expression of key inflammatory mediators (IL2, IL4, IL6, IL12, TNFα, IFNγ, GMCSF, TLR2, TLR4, TLR9, TLR11, TLR12, CD14, IL1β, RANTES, Lactoferrin, and CXCl1) by reverse transcription and probe-based quantitative real-time PCR showed relative mRNA levels higher (p Not Available |
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Date |
2018-11-05T03:47:03Z
2018-11-05T03:47:03Z 2016-07-10 |
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Type |
Research Paper
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Identifier |
Not Available
1596-5996 http://krishi.icar.gov.in/jspui/handle/123456789/9273 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Elsevier
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