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Effect of bone morphogenetic protein-2 (BMP-2) on sheep granulosa cell steroidogenic function

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Title Effect of bone morphogenetic protein-2 (BMP-2) on sheep granulosa cell steroidogenic function
Not Available
 
Creator Vinod Kumar D
Gulzar R
Selvaraju S
Nazar S
Parthipan S
Anand
Prasad RV
Jamuna KV
Ravindra JP
 
Subject Bone morphogenetic protein-2 (BMP-2)
Granulosa cell
Estradioal
 
Description Not Available
The bone morphogenetic protein-2 (BMP-2) has been implicated in follicle growth
and steroidogenic functions of the ovary. The BMP-2 belongs to the BMPs subfamily of TGF-β
superfamily. The present study was carried out in sheep granulosa cell culture to study the effect
of different doses ofBMP-2 0ng/ml (control group), 30ng/ml, 50ng/ml and 100ng/ml on granulosa
cell steriodogenic function. For functional studies, granulosa cells were obtained from ovarian
follicles 1–3 mm in diameter. The cells were cultured for 6 daysin serum-free medium containing
androstenedione and LR3-IGF-I. The medium was replaced for every two days and the spent
medium was used to assess the concentration of estradiol 17-β in cultured granulosa cells by
radioimmunoassay. The BMP-2 at all the three different doses increased the estradioal 17-β
production when compared to control group of treatment (P
Not Available
 
Date 2018-11-22T22:58:30Z
2018-11-22T22:58:30Z
2014-01-01
 
Type Research Paper
 
Identifier Vinod Kumar D, Gulzar R, Selvaraju S, Nazar S, Parthipan S, Anand, Prasad RV, Jamuna KV and Ravindra JP. 2014. Effect of bone morphogenetic protein-2 (BMP-2) on sheep granulosa cell steroidogenic function. Journal of Cell and Tissue Research, 14:4233-4236.
0973-0028
http://krishi.icar.gov.in/jspui/handle/123456789/12859
 
Language English
 
Relation Not Available;
 
Publisher CTR Publications