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An overview of heterologous expression host systems for the production of recombinant proteins

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Title An overview of heterologous expression host systems for the production of recombinant proteins
Not Available
 
Creator Gomes AR
Byregowda SM
Veeregowda BM
Balamurugan V
 
Subject Expression host systems
Heterologous proteins
Production
Prokaryotic
Eukaryotic
 
Description Not Available
With the advent of recombinant DNA technology, cloning and expression of numerous mammalian genes
in different systems have been explored to produce many therapeutics and vaccines for human and animals in the form
of recombinant proteins. But selection of the suitable expression system depends on productivity, bioactivity, purpose
and physicochemical characteristics of the protein of interest. However, large scale production of recombinant proteins
is still an art in spite of increased qualitative and quantitative demand for these proteins. Researchers are constantly
challenged to improve and optimise the existing expression systems, and also to develop novel approaches to face the
demands of producing the complex proteins. Here, we concisely review the most frequently used conventional and
alternative host systems, with their unique features, along with advantages and disadvantages and their potential applications
for the production of recombinant products.
Not Available
 
Date 2018-11-06T03:36:47Z
2018-11-06T03:36:47Z
2016-07-01
 
Type Research Paper
 
Identifier Not Available
2307-8316
http://krishi.icar.gov.in/jspui/handle/123456789/9425
 
Language English
 
Relation Not Available;
 
Publisher Nexus Academic Publisher