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Gene expression and silencing of activin receptor type 2A (ACVR2A) in myoblast cells of chicken

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Title Gene expression and silencing of activin receptor type 2A (ACVR2A) in myoblast cells of chicken
Not Available
 
Creator Satheesh, P., Bhattacharya, T. K., Kumar, P., Chatterjee, R. N., Dhara, S. K., Paswan, C., Shukla, R. and Dushyanth, K.
 
Subject nil
 
Description Not Available
1. Activin receptor type 2A (ACVR2A) acts as receptor for myostatin (MSTN) protein involved in
inhibiting satellite cell proliferation and differentiation. The importance of the ACVR2A gene during
embryonic and post-hatch periods in broiler and layer chicken was studied in an in vitro cell culture system.
2. The expression pattern of the ACVR2A gene during embryonic stages was similar in broiler and layer
lines. Post-hatch expression of the ACVR2A gene varied significantly between broiler and layer lines.
3. Five shRNA molecules were designed to knockdown expression of the ACVR2A gene in chicken
myoblast cells. The silencing of the ACVR2A gene in a cell culture system varied from 60% to 82%.
4. It is concluded that between broiler and layer lines, there were no significant changes in expression of
the ACVR2A gene during embryonic stages but it varied significantly during the post-hatch period. The
shRNA showed silencing of the ACVR2A gene under an in vitro cell culture system.
Not Available
 
Date 2018-11-09T05:38:04Z
2018-11-09T05:38:04Z
2016-12-01
 
Type Research Paper
 
Identifier Not Available
1466-1799
http://krishi.icar.gov.in/jspui/handle/123456789/9831
 
Language English
 
Relation Not Available;
 
Publisher Taylor and Francis