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Quantitative expression of hepatic Toll-Like Receptor 1-10 mRNA in Osmanabadi goats during different climatic stresses

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Title Quantitative expression of hepatic Toll-Like Receptor 1-10 mRNA in Osmanabadi goats during different climatic stresses
Not Available
 
Creator Sophia I
Sejian V
Bagath M
Bhatta R
 
Subject Climate change
Combined stress
GoatsHeat stress
Immune response
Nutritional stress
TLR
 
Description Not Available
A study was conducted to establish the impact of heat stress, nutritional stress and the combined effect of both stresses (heat and nutrition) on the expression of toll-like receptors (TLRs) genes in liver samples of Osmanabadi goats. Twenty-four adult male Osmanabadi goats (average body weight 16.0 kg) were divided into four equal groups of six each: control (C), heat stress (HS), nutritional stress (NS) and combined stress (CS). The study was conducted over a 45 day period. The C and HS goats had ad libitum access to their feed while NS and CS goats were restricted feed (30% intake of C) to induce nutritional stress. The HS and CS goats were exposed to solar radiation for six hours a day between 10:00 h–16:00 h to induce heat stress. The animals were slaughtered at the end of the study and their livers were sampled for different TLRs gene expression assay. Among the different TLRs studied, TLR1, TLR3, TLR6, TLR7, TLR8 and TLR10 mRNA expressions were significantly (P < 0.05) higher in HS group as compared to other groups (C, NS and CS). The significantly higher levels of TLR1, TLR3, TLR6, TLR7, TLR8 and TLR10 mRNA expression in HS groups indicated that, when nutrition is not compromised, heat stressed animals were able to maintain their immune functions against heat shock proteins. This suggests that improving nutrition during heat stress condition may be highly beneficial to maintaining the immune status against heat shock proteins of the goats. The higher expression of TLR8 and TLR10 in the HS group indicates that these two genes may act as the immunological markers of heat stress in goats.
Not Available
 
Date 2018-11-25T01:15:19Z
2018-11-25T01:15:19Z
2016-06-11
 
Type Research Paper
 
Identifier Sophia I, Sejian V, Bagath M and Bhatta R. 2016. Quantitative expression of hepatic Toll-Like Receptor 1-10 mRNA in Osmanabadi goats during different climatic stresses. Small Ruminant Research, 141:11-16.
0921-4488
http://krishi.icar.gov.in/jspui/handle/123456789/13205
 
Language English
 
Relation Not Available;
 
Publisher Elsevier