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Expression pattern of BMPR-2 and Fas and the regulatory role of BMP-2 and IGF-1 on granulosa cells function in buffalo.

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Title Expression pattern of BMPR-2 and Fas and the regulatory role of BMP-2 and IGF-1 on granulosa cells function in buffalo.
EFFECT OF BMP-2, IGF-1 AND FAS ON GRANULOSA CELLS FUNCTION
 
Creator Vinodkumar D
Gulzar R
Selvaraju S
Nazar S
Parthipan S
Jamuna K
Prasad R
Ravindra JP
 
Subject Buffalo
BMP-2
Estradiol-17
Fas-L
Follicles
IGF-1
 
Description Not Available
The expression pattern of BMPR-2 and Fas was investigated in different developmental stages (1–3 mm, 3–5
mm, 5–8 mm and >8 mm) of follicles and the effect of bone morphogenetic protein-2 (BMP-2), insulin-like growthfactor-1 (IGF-1) and Fas-ligand (Fas-L) was studied in vitro on granulosa cell function. BMPR-2 was mainlylocalized in the granulosa cells, oocytes and theca cells of healthy follicles from primordial to late antral stages and the expression pattern did not differ among different sizes of follicles. The Fas was predominantly expressed in granulosa cells of atretic follicles. In the granulosa cell culture, BMP-2 (30 ng/ml) and IGF-1 (100 ng/ml) significantly increased estradiol-17 production when compared to control in all sizes i.e. small (3–5 mm), medium (5–8 mm) and large (>8 mm) follicles. This first study in buffalo revealed that BMP-2 rescues small size follicles, whereas IGF-1 rescues all size follicles from Fas mediated apoptosis in buffalo.
National Agricultural Innovation Project (NAIP)- C1056, ICAR
 
Date 2018-11-25T02:07:48Z
2018-11-25T02:07:48Z
2017-01-01
 
Type Research Paper
 
Identifier Vinodkumar D, Gulzar R, Selvaraju S, Nazar S, Parthipan S, Jamuna K, Prasad R and Ravindra JP. 2017. Expression pattern of BMPR-2 and Fas and the regulatory role of BMP-2 and IGF-1 on granulosa cells function in buffalo. Indian Journal of Animal Sciences, 87:45-48.
0367-8318
http://krishi.icar.gov.in/jspui/handle/123456789/13216
 
Language English
 
Relation Not Available;
 
Publisher Indian Council of Agricultural Research