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Protective role of epigallocatechin-3-gallate on arsenic induced testicular toxicity in Swiss albino mice

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Title Protective role of epigallocatechin-3-gallate on arsenic induced testicular toxicity in Swiss albino mice
Not Available
 
Creator Guvvala PR
Ravindra JP
Rajani CV
Sivaram M
Selvaraju S
 
Subject Arsenic
EGCG
Spermatogenesis
Spermatozoa function
Oxidative stress
Lipid peroxidation
 
Description Not Available
Arsenic, often referred to as the king of poisons is carcinogenic in humans and animals. It affects multiorgan systems including reproduction. The present study was undertaken to explore the protective role of green tea compound, epigallocatechin-3-gallate (EGCG) on arsenic induced testicular toxicity in Swiss albino mice. Thirty two adult male mice were randomly assigned to four groups (n=8). Group I served as control without test chemical. The group II received arsenic (200ppm) through drinking water, group III received only EGCG (20mg/kgb.wt., intraperitoneally, alternate days) and group IV was administered arsenic+EGCG for 40days. Factorial experimental design was employed to assess the treatment effect. The EGCG restored arsenic induced decrements in epididymal sperm concentration, kinematic attributes (total motility, rapid, progressive motile, fast progressive, VSL, VAP, VCL, BCF, LIN, WOB, STR and Type A), structutal membrane integrity, functional membrane integrity and mitochondrial membrane potential. As evidenced by the histoarchitectural studies, the EGCG reversed the deleterious effects of arsenic on testicular malondialdehyde (p
Not Available
 
Date 2018-11-23T07:09:42Z
2018-11-23T07:09:42Z
2017-12-01
 
Type Research Paper
 
Identifier Guvvala PR, Ravindra JP, Rajani CV, Sivaram M and Selvaraju S. 2017. Protective role of epigallocatechin-3-gallate on arsenic induced testicular toxicity in Swiss albino mice. Biomedicine and Pharmacotherapy, 96:685-694.
0753-3322
http://krishi.icar.gov.in/jspui/handle/123456789/12929
 
Language English
 
Relation Not Available;
 
Publisher Elsevier