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Foot-and-Mouth Disease Virus-Associated Abortion and Vertical Transmission following Acute Infection in Cattle under Natural Conditions

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Title Foot-and-Mouth Disease Virus-Associated Abortion and Vertical Transmission following Acute Infection in Cattle under Natural Conditions
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Creator Rajeev Ranjan1*, Jitendra K. Biswal1, Saravanan Subramaniam1, Karam Pal Singh2, Carolina Stenfeldt3,4, Luis L. Rodriguez3, Bramhadev Pattnaik1, Jonathan Arzt3*
 
Subject FMDV, Abortion, Vertical Transmission, Cattle
 
Description Not Available
Foot-and-mouth disease (FMD) is a highly contagious and economically important viral disease
of cloven-hoofed animals, including domestic and wild host species. During recent
FMD outbreaks in India, spontaneous abortions were reported amongst FMD-affected and
asymptomatic cows. The current study was an opportunistic investigation of these naturally
occurring bovine abortions to assess causality of abortion and vertical transmission of
FMDV from infected cows to fetuses. For this purpose, fetal tissue samples of eight abortuses
(heart, liver, kidney, spleen, palatine tonsil, umbilical cord, soft palate, tongue, lungs,
and submandibular lymph node) were collected and screened by various detection methods,
including viral genome detection, virus isolation, and immunomicroscopy. Amongst
these cases, gross pathological changes were observed in 3 abortuses. Gross pathological
findings included blood-tinged peritoneal and pleural effusions and myocarditis. Hearts of
infected calves had mild to moderate degeneration and necrosis of the myocardium with
moderate infiltration by mixed inflammatory cells. Localization of FMDV antigen was demonstrated
in lungs and soft palate by immunomicroscopy. FMDV serotype O viral genome was
recovered from 7 of 8 cases. Infectious FMDV serotype O was rescued by chemical transfection
of the total RNA extracted from three soft palate samples and was sequenced to confirm
100% identity of the VP1 (capsid) coding region with isolates collected from infected
cattle during the acute phase of infection. Based upon these findings, it may be concluded
that FMDV-associated abortion occurred among the infected pregnant cows included within
this study and FMDV was subsequently transmitted vertically to fetuses. This is the first documentation
of FMDV-associated abortions in cattle.
Not Available
 
Date 2018-11-26T13:50:23Z
2018-11-26T13:50:23Z
2016-12-15
 
Type Research Paper
 
Identifier Ranjan R, Biswal JK, Subramaniam S, Singh KP, Stenfeldt C, Rodriguez LL, et al. (2016) Foot-and-Mouth Disease Virus-Associated Abortion and Vertical Transmission following Acute Infection in Cattle under Natural Conditions. PLoS ONE 11(12): e0167163. doi:10.1371/journal. pone.0167163
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/13486
 
Language English
 
Relation Not Available;
 
Publisher PLOS One