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Role of MAPK/MNK1 signaling in virus replication

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Title Role of MAPK/MNK1 signaling in virus replication
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Creator Ram Kumar, Nitin Khandelwal, Riyesh Thachamvally, Bhupendra Nath Tripathi, Sanjay Barua, Sudhir Kumar Kashyap, Sunil Maherchandani, Naveen Kumar
 
Subject Signaling pathway MAPK MNK1 Virus replication Antiviral drugs
 
Description Not Available
Viruses are obligate intracellular parasites; they heavily depend on the host cell machinery to effectively replicate
and produce new progeny virus particles. Following viral infection, diverse cell signaling pathways are
initiated by the cells, with the major goal of establishing an antiviral state. However, viruses have been shown to
exploit cellular signaling pathways for their own effective replication. Genome-wide siRNA screens have also
identified numerous host factors that either support (proviral) or inhibit (antiviral) virus replication. Some of the
host factors might be dispensable for the host but may be critical for virus replication; therefore such cellular
factors may serve as targets for development of antiviral therapeutics. Mitogen activated protein kinase (MAPK)
is a major cell signaling pathway that is known to be activated by diverse group of viruses. MAPK interacting
kinase 1 (MNK1) has been shown to regulate both cap-dependent and internal ribosomal entry sites (IRES)-
mediated mRNA translation. In this review we have discuss the role of MAPK in virus replication, particularly
the role of MNK1 in replication and translation of viral gen
Not Available
 
Date 2018-12-01T07:13:03Z
2018-12-01T07:13:03Z
2018-01-01
 
Type Article
 
Identifier https://doi.org/10.1016/j.virusres.2018.05.028
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/14816
 
Language English
 
Relation Not Available;
 
Publisher Elsevier