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Sodium alginate and gum acacia hydrogels of zinc oxide nanoparticles reduce hemolytic and oxidative stress inflicted by zinc oxide nanoparticles on mammalian cells.

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Title Sodium alginate and gum acacia hydrogels of zinc oxide nanoparticles reduce hemolytic and oxidative stress inflicted by zinc oxide nanoparticles on mammalian cells.
Not Available
 
Creator Raguvaran R, Manuja A, Manuja BK, Riyesh T, Singh S, Kesavan M, Dimri U.
 
Subject nc oxide, nanoparticles, Reactive oxygen species, Oxidative stress, Alginate, Gum acacia, Horse, Lipid peroxidation, MDA, Hemolytic activity
 
Description Not Available
Zinc oxide nanoparticles are important nanomaterials currently under research due
to their applicability in nanomedicine. Toxicity of ZnO NPs has been extensively
studied and has been shown to affect various cell types and animal systems. In
this study, we investigated hemolytic potential and oxidative stress inflicted by
ZnO NPs and ZnO NPs-loaded-sodium alginate-gum acacia hydrogels on horse
erythrocytes and African green monkey kidney (Vero) cells. Our study provides a
better understanding of the hemolytic and oxidative effects of interaction of ZnO
NPs and ZnO NPs released from polymeric hydrogels with the biological system.
Remarkable aggregation of erythrocytes was noted in the higher concentration of
ZnO NPs treated erythrocytes as compared to erythrocytes treated with ZnO
NPs-loaded hydrogels. ZnO NPs-loaded hydrogels treated Vero cells significantly
reduced oxidative stress as evidenced by less malondialdehyde production as
compared to that of ZnO NPs treated cells. Normal horse erythrocytes when treated
with ZnO NPs in in vitro condition undergo oxidative damage, and contribute in
augmenting the toxicity. We demonstrated that polymeric ZnO NPs reduced the
undesirable effects provoked by ZnO NPs on mammalian cells.
Not Available
 
Date 2018-11-29T10:21:01Z
2018-11-29T10:21:01Z
2017-03-31
 
Type Journal
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/14161
 
Language English
 
Relation Not Available;
 
Publisher Not Available