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Cytotoxicity and genotoxicity of a trypanocidal drug quinapyramine sulfate loaded-sodium alginate nanoparticles in mammalian cells.

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Title Cytotoxicity and genotoxicity of a trypanocidal drug quinapyramine sulfate loaded-sodium alginate nanoparticles in mammalian cells.
Not Available
 
Creator Manuja A, Kumar B, Chopra M, Bajaj A, Kumar R, Dilbaghi N, Kumar S, Singh S, Riyesh T, Yadav SC
 
Subject Trypanosoma, Nanomedicine, Genotoxicity, Cytotoxicity, Oxidative stress
 
Description Not Available
We synthesized quinapyramine sulfate loaded-sodium alginate nanoparticles
(QS-NPs) to reduce undesirable toxic effects of QS against the parasite
Trypanosoma evansi, a causative agent of trypanosomosis. To determine the safety
of the formulated nanoparticles, biocompatibility of QS-NPs was determined using
Vero, Hela cell lines and horse erythrocytes in a dose-dependent manner. Our
experiments unveiled a concentration-dependent safety/cytotoxicity (metabolic
activity), genotoxicity (DNA damage, chromosomal aberrations), production of
reactive oxygen species and hemolysis in QS-NPs treated cells. Annexin-V
propidium iodide (PI) staining showed no massive apoptosis or necrosis. However,
at very high doses (more than 300 times than the effective doses), we observed
more toxicity in QS-NPs treated cells as compared to QS treated cells. QS-NPs
were safe at effective trypanocidal doses and even at doses several times higher
than the effective dose
Not Available
 
Date 2018-11-29T10:24:18Z
2018-11-29T10:24:18Z
2016-03-18
 
Type Journal
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/14166
 
Language English
 
Relation Not Available;
 
Publisher Not Available