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Role of MAPK/MNK1 signaling in virus replication

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Title Role of MAPK/MNK1 signaling in virus replication
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Creator Kumar R, Khandelwal N, Thachamvally R, Tripathi BN, Barua S, Kashyap SK, Maherchandani S, Kumar N
 
Subject Signaling pathway, MAPK, MNK1, Virus replication, Antiviral drugs
 
Description Not Available
Viruses are obligate intracellular parasites; they heavily depend on the host
cell machinery to effectively replicate and produce new progeny virus particles.
Following viral infection, diverse cell signaling pathways are initiated by the
cells, with the major goal of establishing an antiviral state. However, viruses
have been shown to exploit cellular signaling pathways for their own effective
replication. Genome-wide siRNA screens have also identified numerous host factors
that either support (proviral) or inhibit (antiviral) virus replication. Some of
the host factors might be dispensable for the host but may be critical for virus
replication; therefore such cellular factors may serve as targets for development
of antiviral therapeutics. Mitogen activated protein kinase (MAPK) is a major
cell signaling pathway that is known to be activated by diverse group of viruses.
MAPK interacting kinase 1 (MNK1) has been shown to regulate both cap-dependent
and internal ribosomal entry sites (IRES)-mediated mRNA translation. In this
review we have discuss the role of MAPK in virus replication, particularly the
role of MNK1 in replication and translation of viral genome.
Not Available
 
Date 2018-11-29T10:27:14Z
2018-11-29T10:27:14Z
2018-06-01
 
Type Journal
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/14171
 
Language English
 
Relation Not Available;
 
Publisher Not Available